A simple fluorometric method for the determination of salicylic acid in aluminium acetylsalicylate
Short Communications
- 64 Downloads
- 1 Citations
Abstract
A simple, rapid fluorometric method for the determination of salicylic acid in aluminium acetylsalicylate is presented. The method is based on the dissolution of aluminium acetylsalicylate in sodium fluoride-hydrochloric acid solution, filtration and dilution with buffer solution pH=4 followed by the fluorometric determination of the liberated salicylic acid. The method was applied successfully to the determination of salicyclic acid in aluminium acetylsalicylate tablets.
Keywords
Public Health Sodium Aluminium Internal Medicine Acid Solution
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- 1.Miles CI, Schenk GH. Fluorescence of acetylsalicylic acid in solution and its measurement in presence of salicylic acid. Anal Chem 1970;43:656–9.Google Scholar
- 2.Guttman DE, Salomon GW. Comparison of methods for the determination of salicylic acid in buffered aspirin tablets. J Pharm Sci 1969:58:120–1.Google Scholar
- 3.Levine J, Weber JD. Determination of free salicylic acid in buffered aspirin tablets. J Pharm Sci 1968;57:631–3.Google Scholar
- 4.Shane N, Miele D. Fluorometric determination of salicylic acid in aspirin products including noninterfering, interfering and buffered substances. J Pharm Sci 1970;59:397–400.Google Scholar
- 5.Shane N, Stillman R. Fluorometric determination of salicylic acid in buffered aspirin products. J Pharm Sci 1971;60:114–6.Google Scholar
- 6.The National Formulary XIII. Washington: American Pharmaceutical Association, 1970:30–2.Google Scholar
- 7.Kirchhoefer RD, Juhl WE. Aspirin — A national survey II: Determination of salicylic acid in bulk aspirin and aspirin formulations by high-pressure liquid chromatography using a fluorescence detector. J Pharm Sci 1980;69:548–50.Google Scholar
- 8.Menouer M, Bouabdellah F, Ghernati HM, Guermouche MH. HPLC of acetylsalicylic (aspirin) (ASA) and salicylic acids (SA), optimal conditions for trace analysis of SA in ASA. J High Resolut Chromatogr Commun 1982;5:267–8.Google Scholar
- 9.Menouer M, Ghernati HM, Bouabdallah F, Guermouche MH. Optimum conditions for separation of salicylic acid and aspirin by HPLC. Application to trace analysis for salicylic acid in aspirin. Analusis 1982;10:172–6.Google Scholar
- 10.Juhl WE, Kirchhoefer RD. Aspirin — A national Survey: Semiautomated determination of aspirin in bulk and tablet formulation and salicylic acid in tablet formulations. J Pharm Sci 1980;69:544–8.Google Scholar
- 11.Kitamura K, Majima R. Determination of salicylic acid in aspirin powder by second derivative ultraviolet spectrometry. Anal Chem 1983;55:54–6.Google Scholar
- 12.Drehsen G, Rohdewald P. Rapid high-performance thin-layer chromatography of salicylic acid, salicylamide, ethoxybenzamide and paracetamol in saliva. J Chromatogr 1981;223:479–83.Google Scholar
- 13.Kelly CA. Review article: Determination of the decomposition of aspirin. J Pharm Sci 1970;59:1053–79.Google Scholar
Copyright information
© Royal Dutch Association for Advancement of Pharmacy 1984