Pharmaceutisch Weekblad

, Volume 14, Issue 3, pp 152–158 | Cite as

Single-dose tolerance and pharmacokinetics of 2-n-propyl-2(E)-pentenoate (Δ2(E)-valproate) in healthy male volunteers

  • R. H. Düsing
Recent Developments on Valproate and its Metabolites


2-n-Propyl-2(E)-pentenoic acid (Δ2(E)-valproate) was administered to healthy volunteers in oral doses of 50–800 mg. The drug was tolerated well and no significant adverse effects were observed. Pharmacokinetic parameters were determined. Valproate and 3-keto-valproate were detected as metabolites.


Drug evaluation Pharmacokinetics 2-n-Propyl-2(E)-pentenoic acid Side effects Valproic acid 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • R. H. Düsing
    • 1
  1. 1.Desitin ArzneimittelHamburg 63Germany

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