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Pharmaceutisch Weekblad

, Volume 14, Issue 3, pp 88–92 | Cite as

Centralized preparation of hazardous drugs

A choice between isolator and laminar airflow
  • P. Larrouturou
  • J. Huchet
  • M. -C. Taugourdeau
Practice/Case Reports

Abstract

In 1987, the manager of the Saint-Joseph Hospital (Paris, France) requested a reorganization of cytotoxic drug preparation. Protection for staff who handle hazardous drugs was the main concern. The conclusions drawn from a first analysis emphasize the advantages of a centralized reconstitution unit against a decentralized system. Subsequently, a workload study and an economic study (investment, maintenance, supplies, staff costs, comparative balance sheet and a 5-year simulation) were carried out, but to choose between a laminar airflow in aseptic room and an isolator in a conventional room. The selected isolator is the first of the conception: the central half-suit uses as a server, and four sleeves located on one side allow two technicians to work in a sterile and closed area without sterile garments.

Keywords

Antineoplastic agents Cost and cost analysis Drug compounding Equipment and supplies Isolator Laminar airflow hood 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • P. Larrouturou
    • 1
  • J. Huchet
    • 1
  • M. -C. Taugourdeau
    • 1
  1. 1.Department of PharmacySaint-Joseph HospitalParis CedexFrance

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