Pharmaceutisch Weekblad

, Volume 14, Issue 3, pp 78–82 | Cite as

Clinical and pharmaceutical aspects in acute poisoning

  • R. G. Van Kesteren
  • D. R. A. Uges


Today there are several methods for treating intoxicated patients. If these patients arrive in hospital in time, the diagnosis is correct and appropriate therapy is instituted, nearly all survive without any physical damage. This is best achieved by team-work between the hospital pharmacist and the physician treating the patient. Both should have a sound knowledge of the toxicological properties of drugs and other poisons and the clinical features which they produce. This article emphasizes the need for close co-operation between the pharmacist and the physician and discusses specific therapeutic measures, such as prevention of absorption, acceleration of elimination, symptomatic therapy and administration of antagonists.


Absorption Antidotes Diagnosis Elimination Iatrogenic intoxication Pharmacists, hospital Pharmacokinetics Physicians 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Sangster B. Klinische toxicologie [Clinical toxicology]. Wageningen: Pudoc, 1987.Google Scholar
  2. 2.
    Tempelaar AF. Iatrogene schade en geneesmiddelen. [Iatrogenic damage and drugs]. Pharm Weekbl 1991;126(18):428–32.Google Scholar
  3. 3.
    Van Kesteren RG, Savelkoul TJF. Het vervoer van patiënten met een intoxicatie [Transport of intoxicated patients]. In: Bruins-Stassen MJP, ed. Bijzondere transporten [Special transports]. Amsterdam: Wetenschappelijke Uitgeverij Medical Transfer, 1990:99–105.Google Scholar
  4. 4.
    Sangster B, Van Heijst ANP, Zimmerman ANE. Vergifting door orphenadrine (Disipal®) [Intoxication by orphenadrine]. Ned Tijdschr Geneeskd 1978;122:988–93.PubMedGoogle Scholar
  5. 5.
    Van Heijst ANP, Pikaar SA. Vergiftigingen (Vademe cum) [Intoxications]. Amsterdam: Elsevier, 1984.Google Scholar
  6. 6.
    Berlinger WG, Spector R, Goldberg MJ, Johnson GF, Quee CK, Berg MJ. Enhancement of theophylline clearance by oral activated charcoal. Clin Pharmacol Ther 1983;33:351–4.PubMedGoogle Scholar
  7. 7.
    Rosenberg PJ, Livingstone DJ, Mc.Lellan BA. Effect of whole-bowel irrigation on the antidotal efficacy of oral activated charcoal. Ann Emerg Med 1988;17:681–3.PubMedGoogle Scholar
  8. 8.
    Newton RW. Physostigmine salicylate in the treatment of tricyclic antidepressant overdosage. JAMA 1975;231:941–3.CrossRefPubMedGoogle Scholar
  9. 9.
    Van Kesteren RG, Rauws AG, De Groot G, Van Heijst ANP. Thallium intoxication. An evaluation of therapy. Intensivmed 1980;17:293–7.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • R. G. Van Kesteren
    • 1
  • D. R. A. Uges
    • 2
  1. 1.Department of Reanimation and Clinical ToxicologyUniversity Hospital UtrechtGA Utrechtthe Netherlands
  2. 2.Department of Pharmacy and ToxicologyUniversity Hospital GroningenRB Groningenthe Netherlands

Personalised recommendations