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Pharmaceutisch Weekblad

, Volume 10, Issue 2, pp 76–79 | Cite as

Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats

  • E. J. Van Hoogdalem
  • A. G. De Boer
  • D. D. Breimer
Original Articles

Abstract

Because of the relatively poor intestinal absorption of ampicillin sodium, efforts have been made to enhance ampicillin absorption by co-administration of absorption promoters. In the present study the enhancing effect of sodium decanoate on rate and extent of rectal ampicillin absorption in rats has been evaluated after rate-controlled and site-controlled delivery of aqueous solutions. Rectal absorption without enhancer was extremely low (8±7%), and the addition of 0.032M sodium decanoate gave comparable values. However, administration in 0.16M decanoate considerably increased ampicillin bioavailability, to 79±30%, whereas the absorption rate was not significantly affected.

Keywords

Absorption, enhancement Administration, rectal Ampicillin Decanoate 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1988

Authors and Affiliations

  • E. J. Van Hoogdalem
    • 1
  • A. G. De Boer
    • 1
  • D. D. Breimer
    • 1
  1. 1.Center for Bio-Pharmaceutical Sciences, Division of Pharmacology, Sylvius LaboratoriesState University of LeidenRA Leidenthe Netherlands

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