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Pharmaceutisch Weekblad

, Volume 4, Issue 3, pp 84–86 | Cite as

Cyclosporin A: correlation between HPLC and RIA serum levels

  • E. Abisch
  • T. Beveridge
  • A. Gratwohl
  • W. Niederberger
  • K. Nussbaumer
  • P. Schaub
  • B. Speck
  • M. Trapp
Short Communications

Abstract

Serum levels of cyclosporin A were analysed in parallel with anhplc and aria method for six patients who received repeated intramuscular and oral doses of this immunosuppressive drug after bone marrow transplantation. A good correlation was found between both methods with a similar time course of the serum curves. Due to cross-reacting metabolites, the values from theria assay were on average 30 to 100% higher than with thehplc assay which is specific for the parent drug.

Keywords

Public Health Bone Marrow Internal Medicine Serum Level Cyclosporin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • E. Abisch
    • 1
  • T. Beveridge
    • 2
  • A. Gratwohl
    • 3
  • W. Niederberger
    • 1
  • K. Nussbaumer
    • 1
  • P. Schaub
    • 1
  • B. Speck
    • 3
  • M. Trapp
    • 1
  1. 1.Biopharmaceutical DepartmentSandoz Ltd.BasleSwitzerland
  2. 2.Experimental Therapeutics DepartmentSandoz Ltd.BasleSwitzerland
  3. 3.Division of Haematology, Department of Internal MedicineUniversity of BasleBasleSwitzerland

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