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Pharmaceutisch Weekblad

, Volume 9, Issue 2, pp 91–97 | Cite as

The effect of tick-borne fever on metabolism and renal clearance of sulfadimidine in goats

  • J. F. M. Nouws
  • A. S. J. P. A. M. Van Miert
  • H. Van Gogh
  • A. D. J. Watson
  • T. B. Vree
Pharmacokinetics and Organ Dysfunction

Abstract

The tick-borne fever (TBF) model was used to study the effect of fever on the metabolism of sulfadimidine in goats. During TBF the elimination half-lives were prolonged, and the renal clearance values of sulfadimidine and the majority of its metabolites were markedly diminished compared with those in the uninfected state. During TBF the steady-state levels of the hydroxy metabolites were markedly increased. TBF reduced the extent of hydroxymethylation of the pyrimidine side chain; TBF did not affect acetylation of sulfadimidine. In one goat a progressive accumulation of the metabolites was noticed.

Key words

Clearance, renal Goats Kidney diseases Metabolism Sulfadimidine Tick-borne fever 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1987

Authors and Affiliations

  • J. F. M. Nouws
    • 1
  • A. S. J. P. A. M. Van Miert
    • 2
  • H. Van Gogh
    • 2
  • A. D. J. Watson
    • 3
  • T. B. Vree
    • 4
  1. 1.AA NijmegenThe Netherlands
  2. 2.Department of Veterinary Pharmacology, Pharmacy and ToxicologyFaculty of Veterinary MedicineTD UtrechtThe Netherlands
  3. 3.Department of Veterinary Clinical StudiesUniversity of SydneyAustralia
  4. 4.Department of Clinical PharmacySt. Radboud HospitalHB NijmegenThe Netherlands

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