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Pharmaceutisch Weekblad

, Volume 6, Issue 1, pp 32–38 | Cite as

The effects of immunosuppressive drugs on human immunocompetence

  • P. Th. A. Schellekens
  • R. J. M. Ten Berge
Congress ‘Blood and Drugs’

Abstract

Immunosuppressive drugs are agents capable of suppressing the development of at least one type of immune responsein vivo at doses with minimal side-effects.

After an introduction in which different types of immune responses are briefly discussed, some characteristics regarding the mechanism of action of prednisolone, azathioprine, cylophosphamide and anti-lymphocyte serum (ALS) will be reviewed. Corticosteroids display mainly an anti-inflammatory effect. The immunosuppressive effect of azathioprine is questionable, cyclophosphamide influences the immune system itself and ALS suppresses fairly specific cellular immunity.

Keywords

Public Health Immune Response Internal Medicine Immune System Corticosteroid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

General reading list

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General reading list

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • P. Th. A. Schellekens
    • 1
    • 2
  • R. J. M. Ten Berge
    • 1
    • 2
  1. 1.Laboratory of Experimental and Clinical ImmunologyUniversity of AmsterdamThe Netherlands
  2. 2.Central Laboratory of the Netherlands Red Cross Blood Transfusion ServiceAD AmsterdamThe Netherlands

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