Pharmaceutisch Weekblad

, Volume 6, Issue 1, pp 32–38 | Cite as

The effects of immunosuppressive drugs on human immunocompetence

  • P. Th. A. Schellekens
  • R. J. M. Ten Berge
Congress ‘Blood and Drugs’


Immunosuppressive drugs are agents capable of suppressing the development of at least one type of immune responsein vivo at doses with minimal side-effects.

After an introduction in which different types of immune responses are briefly discussed, some characteristics regarding the mechanism of action of prednisolone, azathioprine, cylophosphamide and anti-lymphocyte serum (ALS) will be reviewed. Corticosteroids display mainly an anti-inflammatory effect. The immunosuppressive effect of azathioprine is questionable, cyclophosphamide influences the immune system itself and ALS suppresses fairly specific cellular immunity.


Public Health Immune Response Internal Medicine Immune System Corticosteroid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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General reading list

  1. Bach JF. The mode of action of immunosuppressive agents. Amsterdam: North Holland Publishing Co., 1975.Google Scholar
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General reading list

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  5. Ten Berge RJM, Schellekens PThA. A critical analysis of the use of azathioprine in clinical medicine. Neth J Med 1983;26:164–71.PubMedGoogle Scholar
  6. Ten Berge RJM, Van Walbeek HK, Schellekens PThA. Evaluation of the immunosuppressive effects of cyclophosphamide in patients with multiple sclerosis. Clin Exp Immunol 1982;50:495–502.PubMedGoogle Scholar
  7. Heyworth MF. Clinical experience with antilymphocyte serum. Immunol Rev 1982;65:79–97.PubMedGoogle Scholar
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • P. Th. A. Schellekens
    • 1
    • 2
  • R. J. M. Ten Berge
    • 1
    • 2
  1. 1.Laboratory of Experimental and Clinical ImmunologyUniversity of AmsterdamThe Netherlands
  2. 2.Central Laboratory of the Netherlands Red Cross Blood Transfusion ServiceAD AmsterdamThe Netherlands

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