Pharmaceutisch Weekblad

, Volume 5, Issue 2, pp 77–78 | Cite as

Distinction between the tautomeric forms of sulfanilamide derivatives by13C- NMR

Short Communications


The application of13C-nmr for the distinction between amido and imido tautomers of sulfanilamide derivatives indmso solution is described. The differentiation is based on Δδ, the change in chemical shift of a sulfanilamide from the neutral form (indmso solution) to the anion (in aqueous alkaline solution). The Δδ values of three C atoms (C1, C1′, C4) are suitable for the differentiation between the tautomers. The conclusions confirm previous results.


Public Health Internal Medicine Chemical Shift Alkaline Solution Sulfanilamide 
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  1. Bult, A., andH.B. Klasen (1978)Pharm. Weekbl. 113, 665–672.Google Scholar
  2. Chang, C., H.G. Floss andG.E. Peck (1975)J. Med. Chem. 18, 505–509.Google Scholar
  3. Chiang, H-C., andC-H. Ch'ien (1979)J. Chinese Chem. Soc. 26, 111–116.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • A. Bult
    • 1
  1. 1.Department of Pharmaceutical Analysis and Analytical ChemistryState University of LeidenRA LeidenThe Netherlands

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