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Pharmaceutisch Weekblad

, Volume 5, Issue 2, pp 77–78 | Cite as

Distinction between the tautomeric forms of sulfanilamide derivatives by13C- NMR

Short Communications

Abstract

The application of13C-nmr for the distinction between amido and imido tautomers of sulfanilamide derivatives indmso solution is described. The differentiation is based on Δδ, the change in chemical shift of a sulfanilamide from the neutral form (indmso solution) to the anion (in aqueous alkaline solution). The Δδ values of three C atoms (C1, C1′, C4) are suitable for the differentiation between the tautomers. The conclusions confirm previous results.

Keywords

Public Health Internal Medicine Chemical Shift Alkaline Solution Sulfanilamide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Bult, A., andH.B. Klasen (1978)Pharm. Weekbl. 113, 665–672.Google Scholar
  2. Chang, C., H.G. Floss andG.E. Peck (1975)J. Med. Chem. 18, 505–509.Google Scholar
  3. Chiang, H-C., andC-H. Ch'ien (1979)J. Chinese Chem. Soc. 26, 111–116.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • A. Bult
    • 1
  1. 1.Department of Pharmaceutical Analysis and Analytical ChemistryState University of LeidenRA LeidenThe Netherlands

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