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Pharmaceutisch Weekblad

, Volume 5, Issue 2, pp 74–76 | Cite as

Comparison of lung deposition of a solution after nebulization by three commonly used portable nebulizers

  • R. A. Foulds
  • L. O. M. J. Smithuis
Short Communications

Abstract

The efficacy of small portable nebulizers is often assumed by patients, pharmacists and physicians. Three healthy volunteers inhaled a mixture of sodium cromoglycate solution mixed with aqueous technetium-99 nebulized by each of three nebulizers and the distribution of radioactivity was detected by gamma scintigraphy. Unexpectedly large differences in the total amount of tracer delivered to the lungs were detected. The possible mechanisms and implications are discussed but it is clear that more information on the performance of individual nebulizers should be available.

Keywords

Public Health Sodium Internal Medicine Healthy Volunteer Cromoglycate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Brown K, Gardner JJ, Lockley WJF, Preston JR, Wilkinson DJ. Radioimmunoassay of sodium cromoglycate in human plasma. Ann Clin Biochem, in press.Google Scholar
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    Cox JSG, Beach JE, Blair AMJN, et al. Disodium cromoglycate (Intal). Adv Drug Res 1970;5:115–96.Google Scholar
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    Task Group on Lung Dynamics. Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys 1966;12:173–207.Google Scholar
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    Hatch T, Gross P. Pulmonary retention and deposition of aerosols. New York: Academic Press, 1964.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • R. A. Foulds
    • 1
  • L. O. M. J. Smithuis
    • 2
  1. 1.Fisons BVAM LeusdenThe Netherlands
  2. 2.Department of Nuclear MedicineSt. Lambertus HospitalAB HelmondThe Netherlands

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