Advertisement

Pharmaceutisch Weekblad

, Volume 5, Issue 2, pp 70–73 | Cite as

Determination of phenol in the presence of resorcinol applying substitution with excess bromine water; structure of the bromination products

  • S. M. Dreijer Van Der Glas
  • T. Schalekamp
  • H. J. De Jong
  • A. Bult
Short Communications
  • 46 Downloads

Abstract

Bromination with a large excess of bromine results in the formation of a tetrabromo product for phenol and a pentabromo derivative for resorcinol. It is possible to determine the active bromine in the tetrabromo product after its isolation by filtration. This can also be done in the presence of resorcinol as its pentabromo derivative does not precipitate. The method gives good results (96–97%±1%) for quantities of 8 mg and higher of phenol in the presence of a maximum of 25 mg resorcinol. From the1H- and13C-nmr spectra of the bromination products it could be concluded that they have a quinoidal structure.

Keywords

Public Health Internal Medicine Phenol Bromine Resorcinol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kolthoff, I.M. (1932)Pharm. Weekbl. 69, 1147–1158.Google Scholar
  2. Kolthoff, I.M., andR. Belcher (1957)Volumetric Analysis III. Interscience Publishers, New York, 534–536.Google Scholar
  3. Price, J.A. (1955)J. Am. Chem. Soc. 77, 5436–37.Google Scholar
  4. Schulek, E., andK. Burger (1958a)Z. Anal. Chem. 161, 184–191;Ibidem (1958b)Acta Chim. Acad. Sci. Hung. 17, 211–224.Google Scholar
  5. Trischler, F. (1968)Acta Pharm. Hung. 38 (6) 384–390.Google Scholar
  6. Wehrli, F.V., andT. Wirthlin (1976)Interpretation of 13 C-NMR Spectra. Heyden & Son, London, 33.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • S. M. Dreijer Van Der Glas
    • 1
  • T. Schalekamp
    • 2
  • H. J. De Jong
    • 1
  • A. Bult
    • 1
  1. 1.Department of Pharmaceutical Analysis and Analytical ChemistryUniversity of Leiden, Gorlaeus LaboratoriesRA LeidenThe Netherlands
  2. 2.Apotheek de VrijheidAP PapendrechtThe Netherlands

Personalised recommendations