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Pharmaceutisch Weekblad

, Volume 5, Issue 2, pp 65–69 | Cite as

In vitro testing of controlled release theophylline preparations: Theolair ®, Theograd® and Theolin®

  • J. P. Crombeen
  • C. J. De Blaey
Original Articles

Abstract

Three dissolution methods,i.e. a paddle type, theusp disintegration and a column method, were used to characterize the release from three controlled release theophylline preparations,i.e. Theolair Retard® 250, Theolin Retard® 300 and Theograd® 350. The release profiles proved to be dependent upon agitation intensity and pH or a combination of both, but the sensitivity towards these variables differed markedly between the products tested.

Keywords

Public Health Internal Medicine Theophylline Control Release Release Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • J. P. Crombeen
    • 1
  • C. J. De Blaey
    • 1
  1. 1.Department of Pharmaceutics, Pharmaceutical LaboratoryUniversity of UtrechtGH UtrechtThe Netherlands

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