Pharmaceutisch Weekblad

, Volume 5, Issue 2, pp 57–60 | Cite as

Formulation of a stable vidarabine infusion fluid

  • L. M. L. Stolk
  • W. Huisman
  • H. D. Nordemann
  • A. Vyth
Original Articles


Decomposition of vidarabine in a 5% glucose infusion fluid after steam sterilization was measured byhplc andtlc analysis. After sterilization for 60 minutes at 100°C and 20 minutes at 120°C no degradation could be observed. A slight but significant degradation was observed after sterilization for 60 minutes at 120°C followed by storage for eight months. Assuming 5% loss of content to be acceptable, it was concluded that a vidarabine infusion fluid can be sterilized for 20 minutes at 120°C and stored at room temperature for at least eight months afterwards.


Public Health Glucose Internal Medicine Infusion Fluid Glucose Infusion 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • L. M. L. Stolk
    • 1
  • W. Huisman
    • 1
  • H. D. Nordemann
    • 2
  • A. Vyth
    • 1
  1. 1.Pharmacy of the University Hospital of AmsterdamAZ AmsterdamThe Netherlands
  2. 2.Faculty of FarmacyUniversity of AmsterdamTV AmsterdamThe Netherlands

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