Pharmaceutisch Weekblad

, Volume 5, Issue 1, pp 9–14 | Cite as

Spasmolytic activity of the flavonoids from Thymus vulgaris

  • C. O. Van Den Broucke
  • J. A. Lemli
Original Articles


Flavonoids fromThymus vulgaris L. have been studiedin vitro for spasmolytic activity on the smooth muscles of the guinea-pig ileum and trachea and of the rat vas deferens. The flavones and thyme extracts inhibit responses to agonists which stimulate specific receptors (acetylcholine, histamine,l-noradrenaline) as well as to agents whose actions are not mediated via specific receptors (BaCl2). Cumulative dose-response curves point to a non-competitive antagonism. Inhibition of Ca2+ contractions on K+ depolarized smooth muscles suggest inhibition of availability of Ca2+ for muscle contraction. pD′2 values were determined to compare the potency of these components to each other and to standard drugs. Flavones induce relaxation of the carbachol contracted tracheal strip without stimulation of the β2-receptors, which were blocked by propranolol.


Public Health Internal Medicine Smooth Muscle Flavonoid Acetylcholine 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • C. O. Van Den Broucke
    • 1
  • J. A. Lemli
    • 1
  1. 1.Laboratory of Pharmaceutical Biology and PhytopharmacologyCatholic University of LeuvenLeuvenBelgium

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