Flavones and flavonol glycosides fromEupatorium cannabinum L.
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Abstract
The 6-methoxyflavones hispidulin and eupafolin have been identified for the first time from the aerial parts ofEupatorium cannabinum L. The presence of the previously known flavonol glycosides astragalin, kaempferol-3-rutinoside, hyperoside, isoquercitrin and rutin could be confirmed. Hispidulin, eupafolin and rutin were screened for cytotoxicityin vitro.
Keywords
Asteraceae Eupafolin Eupatorium cannabinum Flavones Flavonol glycosides HispidulinPreview
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References
- 1.Woerdenbag HJ.Eupatorium cannabinum L. A review emphasizing the sesquiterpene lactones and their biological activity. Pharm Weekbl [Sci] 1986;8:245–51.Google Scholar
- 2.Woerdenbag HJ, Konings AWT. Investigation of the antitumour action of eupatoriopicrin against the Lewis lung tumour. Planta Med 1987;53:318–22.PubMedGoogle Scholar
- 3.Woerdenbag HJ, Malingré ThM, Lemstra W, Konings AWT. Cytostatic activity of eupatoriopicrin in fibrosarcoma bearing mice. Phytother Res 1987;1:76–9.Google Scholar
- 4.Hendriks H, Balraadjsing W, Huizing HJ, Bruins AP. Investigation into the presence of pyrrolizidine alkaloids inEupatorium cannabinum by means of positive and negative chemical ionization GC-MS. Planta Med 1987; 53:456–61.Google Scholar
- 5.Pagani T, Romussi G. Constituents ofEupatorium cannabinum var.syriacum. Farmaco [Prat] 1967;22:771–85.Google Scholar
- 6.Aquino R, D'Agostino M, Domestico M, Senatore F. Flavonoid glycosides fromEupatorium cannabinum subsp.cannabinum. Fitoterapia 1988;59:236–8.Google Scholar
- 7.Oswiecimska M, Sandra G.Eupatorium cannabinum L. Search for biologically active fraction. Diss Pharm Pharmacol 1972;23:475–83.Google Scholar
- 8.Stefanovic M, Solaja B, Dermanovic M, Milavanovic. Chemical investigations of the plant species ofEupatorium cannabinum L. (Compositae). J Serb Chem Soc 1986;51:575–81.Google Scholar
- 9.Kupchan SM, Sigel CW, Hemingway RJ, Knox JR, Udayamurthy MS. Tumor inhibitors XXXIII. Cytostatic flavones fromEupatorium species. Tetrahedron 1969;25: 1603–15.PubMedGoogle Scholar
- 10.Ulubelen A, Oksüz S. Cytostatic flavones fromCentaurea urvillei. J Nat Prod 1982;45:373.Google Scholar
- 11.Tutin TG, Heywood VH, Burges NA, et al. Flora Europaea Vol. 4. Cambridge: Cambridge University Press, 1976:109.Google Scholar
- 12.Neu R. Chelate von Diarylborsäuren mit aliphatischen Oxyalkylaminen als Reagenzien für den Nachweis von Oxyphenyl-benzo-Ÿ-pyronen. Naturwissenschaft 1957; 44:181–2.Google Scholar
- 13.Wagner H, Bladt S, Zgainski EM. Drogenanalyse. Berlin: Springer-Verlag, 1983:299.Google Scholar
- 14.Sondheimer E, Szymanski CD, Corse JW. J Agric Food Chem 1961;9:146–9.Google Scholar
- 15.Woerdenbag HJ, Hendriks H, Malingré ThM, Van Stralen R, Van der Berg KJ, Konings AWT.In vitro cytotoxity of sesquiterpene lactones fromEupatorium cannabinum L. and semisynthetic derivations from eupatoriopicrin. Phytother Res 1988;2:109–14.Google Scholar
- 16.Mabry TJ, Markham KR, Thomas MB. The systematic identification of flavonoids. Berlin: Springer-Verlag, 1970.Google Scholar
- 17.Ulubelen A, Timmermann BN, Mabry TJ. Flavonoids fromBrickellia chlorolepis andB. dentata. Phytochemistry 1980;19:905–8.Google Scholar
- 18.Roberts MF, Timmermann BN, Mabry TJ. 6-Methoxyl flavonols fromBrickellia veronicaefolia (Compositae). Phytochemistry 1980;19:127–9.Google Scholar
- 19.Goodwin RS, Rosler KH, Mabry TJ, Varma SD. Flavonoids fromBrickellia glutinosa. J Nat Prod 1984;47: 711–4.PubMedGoogle Scholar
- 20.Samuels Brusse F, Furst R, Van Bennekom WP. Amberlite XAD-2, een literatuuroverzicht [Amberlite XAD-2, a literature review]. Pharm Weekbl 1974;109:921–9.Google Scholar
- 21.Rosler KH, Goodwin RS. A general use of XAD-2 resin for the purification of flavonoids from aqueous fractions. J Nat Prod 1984;47:188.Google Scholar
- 22.Liu YL, Mabry TJ. Flavonoids fromArtemisia ludoviciana var.ludoviciana. Phytochemistry 1982;21:209–14.Google Scholar
- 23.Mears JA, Mabry TJ. A procedure for the UV detection of hydroxyl and methoxyl groups at C6 in flavones and 3-O-substituted flavonols. Phytochemistry 1972;11: 411–2.Google Scholar
- 24.Voirin B. UV spectral differentiation of 5-hydroxy- and 5-hydroxy-3-methoxy flavones with mono-(4′), di-(3′,4′) or tri-(3′,4′,5′)-substituted B rings. Phytochemistry 1983; 22:2107–45.Google Scholar
- 25.Ferraro G, Martino V, Borrajo G, Coussio JD. 5,7,3′,4′-tetrahydroxy-6-methoxy flavanone fromEupatorium subhastatum. Phytochemistry 1987;26:3092–3.Google Scholar
- 26.Imre S, Tulus R, Sengün I. Flavone and antraquinone pigments inDigitalis species. VIII. Flavones ofDigitalis ferruginea. Phytochemistry 1973;12:2317–8.Google Scholar
- 27.Ferraro GE, Coussio JD. Flavonoids fromEupatorium subhastatum. Phytochemistry 1973;12:1825.Google Scholar
- 28.Herz W, De Groote R, Murari R, Kumar N. Sesquiterpene lactones ofEupatorium serotinum. J Org Chem 1979;44:2784–8.Google Scholar
- 29.Herz W, Govindan SV, Kumar N. Sesquiterpene lactones and other constituents ofEupatorium lancifolium andE. semiserratum. Phytochemistry 1981;20:1343–7.Google Scholar
- 30.Woerdenbag HJ. A fundamental study on the cytostatic action of sesquiterpene lactones fromEupatorium cannabinum L. [Dissertation]. Groningen: University of Groningen, 1988.Google Scholar
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© Royal Dutch Association for Advancement of Pharmacy 1989