The suitability of some preservatives in chloroquine phosphate syrup
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In Third World countries chloroquine phosphate syrup is frequently prepared with chloroform as a preservative. Because of the toxic side effects of chloroform the suitability of a number of possible alternatives were investigated. If the chloroquine phosphate syrup is prepared as such, the combination of sorbic acid (1.5 g/l) and citric acid (2 g/l) is preferred. If, however, the chloroquine phosphate syrup is prepared from a stock solution of simple syrup, the relatively low pH may be undesirable, because it may negatively affect the stability or solubility of other medicinal compounds. For a stock solution of simple syrup the combination of methyl paraben (1.8 g/l) and propyl paraben (0.2 g/l) is preferred. Good care must be taken that a layer of condense water cannot be formed.
KeywordsChloroquine Citric acid Drug stability Parabens Preservatives, pharmaceutical Sorbic acid Syrup
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- 1.Reynold JEF, ed. Martindale. The extra pharmacopoeia. 28th ed. London: The Pharmaceutical Press, 1982:745.Google Scholar
- 2.Silk M. Chloroform content of preserved solutions. Pharm J 1986;237:128–9.Google Scholar
- 3.Anonymous. Sirupus simplex. Formularium der Nederlandse Apothekers. Commentaar. 's-Gravenhage: Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie, 1985.Google Scholar
- 4.Wallhäusser KH. Sterilisation, Desinfektion, Konservierung. Stuttgart: Georg Thieme Verlag, 1978:410.Google Scholar
- 5.Anonymous. United States Pharmacopeia. 20th ed. Rockville: The United States Pharmacopeial Convention, 1980:873.Google Scholar
- 6.Anonymous. British Pharmacopoeia. London: Her Majesty's Stationery Office, 1973:100.Google Scholar
- 7.Anagnostopoulos GD, Kroll RG. Water activity and solute effect on the bacterial action of phenol. Microbios Lett 1978;7:69–74.Google Scholar