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Pharmaceutisch Weekblad

, Volume 10, Issue 3, pp 101–116 | Cite as

Etoposide and teniposide

Bioanalysis, metabolism and clinical pharmacokinetics
  • J. J. M. Holthuis
Review Articles

Abstract

Etoposide (VP 16-213) and teniposide (VM 26) are semisynthetic epipodophyllotoxin derivatives active against a variety of tumours. The clinical efficacy has led to an increasing interest in these compounds. This review presents information on the mechanism of action, biochemical pharmacology, bioanalysis, metabolism and pharmacokinetics of etoposide and teniposide.

Keywords

Chemistry Chromatography Etoposide Immunoassay Metabolism Podophyllotoxin Pharmacokinetics Teniposide 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1988

Authors and Affiliations

  • J. J. M. Holthuis
    • 1
  1. 1.Department of Pharmaceutical Analysis, Faculty of PharmacyState University of UtrechtGH Utrechtthe Netherlands

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