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Pharmaceutisch Weekblad

, Volume 4, Issue 6, pp 165–171 | Cite as

Leukotrienes, allergy and inflammation

  • F. P. Nijkamp
  • J. M. A. Sitsen
Review Articles

Abstract

Immunological and non-immunological injury induce as a result of the action of the enzyme lipoxygenase the release of a series of arachidonic acid metabolites known as leukotrienes. The leukotrienes play an important role in allergic and inflammatory disease. Leukotrienes C4, D4 and E4 which recently have been recognized as constituents of the allergic mediator slow reacting substance of anaphylaxis (srs-a) induce powerful bronchoconstriction, plasma exudation and weal and flare responses. Leukotriene B4 is involved in the regulation of chemotaxis, chemokinesis and other aspects of both cellular and vascular inflammation.

The development of specific lipoxygenase inhibitors may lead to a new class of drugs for the treatment of bronchial asthma and chronic inflammatory diseases.

Keywords

Public Health Asthma Internal Medicine Arachidonic Acid Inflammatory Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • F. P. Nijkamp
    • 1
  • J. M. A. Sitsen
    • 1
  1. 1.Rudolf Magnus Institute for Pharmacology, Medical FacultyState University of UtrechtGD UtrechtThe Netherlands

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