Pharmaceutisch Weekblad

, Volume 8, Issue 4, pp 223–228 | Cite as

Inclusion complexation of warfarin with cyclodextrins to improve some pharmaceutical characteristics

  • Shan-Yang Lin
  • Juei-Chyi Yang
Original Articles


Inclusion complexation of warfarin and α- or β-cyclodextrins in water and in the solid phase were studied by a solubility method, a membrane permeation study, thin-layer chromatography, a dissolution study, IR spectroscopy and differential scanning calorimetry. The solubility of warfarin increased with the addition of cyclodextrins. The apparent stability constants of the α- and β-cyclodextrin complexes are 10.29M−1 and 148.88M−1 respectively. The greater the stability constant of the inclusion complex the lesser the permeability of warfarin. Solid complexes of warfarin and α- or β-cyclodextrins were obtained by freeze-drying. Clear differences in IR absorption spectra and DSC thermograms were observed between the inclusion complexes and physical mixtures. The dissolution rate of the freeze-dried warfarin-cyclodextrin complexes was increased about 1200-fold and 550-fold for α- and β-cyclodextrins, respectively. The dissolution rate of warfarin was significantly improved by complex formation.

Key words

Complexation Cyclodextrins Dissolution Permeability Solubility Warfarin 


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Copyright information

© Bohn, Scheltema & Holkema 1986

Authors and Affiliations

  • Shan-Yang Lin
    • 1
  • Juei-Chyi Yang
    • 1
  1. 1.Biopharmaceutics Laboratory, Department of Medical Research Veterans General HospitalVACRSShih-Pai, TaipeiTaiwan, Republic of China

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