the global indices are valid for clinical application;
in 18.6% of the patients studied there was severe impairment and unacceptable seizure control;
combined types of seizure are difficult to control;
no significant difference is demonstrated between monotherapy and polytherapy regarding the amount of neurotoxicity.
The indices can be determined rapidly and therefore may become valuable aids for the physician in an out-patient clinic to support a decision whether or not to revise current anti-epileptic drug therapy.
KeywordsAnticonvulsants Classification Clinimetrics Drug therapy Drug therapy, combination Epidemiology Epilepsy Rating scales Seizures Side-effects
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- 2.Feinstein AR. Clinimetrics. New Haven: Yale University Press, 1987.Google Scholar
- 5.Gowers WR. Epilepsy and other chronic convulsive diseases. London: Churchill, 1881.Google Scholar
- 6.Reynolds EH. Iatrogenic disorders in epilepsy. In: Williams D, ed. Modern trends in neurology; vol. 5. London: Butterworth, 1970:271–86.Google Scholar
- 7.Rwiza HT, Keyser A, Hekster YA, et al. Retrospective analysis of drug treatment in epileptic patients. Pharm Weekbl [Sci] 1989;11(2):50–5.Google Scholar
- 8.Anonymous. WHO-International Classification of impairments, disabilities and handicaps. Geneva: World Health Organization, 1980.Google Scholar
- 9.Trimble MR. Chronic epilepsy. Its prognosis and management. Chichester: John Wiley & Sons, 1989.Google Scholar
- 10.Meldrum BS. Pathophysiology of chronic epilepsy. In: Trimble MR, ed. Chronic epilepsy. Its prognoses and management. Chichester: John Wiley & Sons, 1989:1–11.Google Scholar