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Pharmaceutisch Weekblad

, Volume 13, Issue 4, pp 179–181 | Cite as

Antibiotic concentrations in the groin wound after vascular prosthetic implantation

  • A. C. Van Loenen
  • H. J. M. Martens
  • A. J. C. Mackaay
  • J. A. Rauwerda
  • F. C. Bakker
  • G. A. Vos
Articles
  • 14 Downloads

Abstract

The kinetics of systemically and locally administered cefuroxime or ceftazidime in wound fluid were investigated in the period after vascular prosthetic implantation. Cefuroxime or ceftazidime was administered intravenously in patients. Simultaneously 250 mg ceftazidime or cefuroxime was added to preclotted blood. Locally administered antibiotics could not be detected in our samples. In groin fluid samples 24–48 h after the operation the average concentration of cefuroxime was 8.3 and of ceftazidime 5.0 mg/l. The decline of the concentration of cefuroxime or ceftazidime in groin fluid seems to be much slower than one would expect from the half-lives of the antibiotics. We conclude that cefuroxime and to a lesser extent ceftazidime are suitable as prophylactic agents in arterial reconstruction.

Keywords

Ceftazidine Cefuroxime Groin Implants, artificial Vascular surgery Pharmacokinetics 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • A. C. Van Loenen
    • 1
  • H. J. M. Martens
    • 1
  • A. J. C. Mackaay
    • 2
  • J. A. Rauwerda
    • 2
  • F. C. Bakker
    • 2
  • G. A. Vos
    • 2
  1. 1.Hospital PharmacyFree University HospitalHV AmsterdamThe Netherlands
  2. 2.Department of Vascular SurgeryFree University HospitalAmsterdam

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