Pharmaceutisch Weekblad

, Volume 13, Issue 4, pp 176–178 | Cite as

Comparative bioavailability of rectal and oral formulations of chloroquine

  • Mathieu M. Tjoeng
  • Paul H. G. Hogeman
  • Harry Kapelle
  • Marcel L. J. De Ridder
  • H. Verhaar


The relative bioavailability of chloroquinone in Witepsol® H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.


Administration, oral Administration, rectal Biological availability Chloroquine Pharmacokinetics 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • Mathieu M. Tjoeng
    • 1
  • Paul H. G. Hogeman
    • 2
  • Harry Kapelle
    • 1
  • Marcel L. J. De Ridder
    • 1
  • H. Verhaar
    • 3
  1. 1.Clinical Pharmacy DepartmentSt. Elisabeth HospitalCP AmersfoortThe Netherlands
  2. 2.St. Elisabeth HospitalAmersfoort
  3. 3.Internal Medicine DepartmentSt. Elisabeth HospitalAmersfoort

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