Pharmaceutisch Weekblad

, Volume 10, Issue 5, pp 217–220 | Cite as

Gamma irradiation of Sennae Folium

Microbiological and phytochemical studies
  • H. Van Doorne
  • E. H. Bosch
  • J. H. Zwaving
  • E. T. Elema
Short Communications


The effect of different doses of gamma irradiation on senna leaves was studied. No changes in sennoside content and composition were observed after irradiation with 25 kGy. It was demonstrated that a minimum dose of 10 kGy was necessary to obtain a product of good microbiological quality. Cold maceration of senna leaves has to be discouraged, because of unavoidable microbial growth. Hot extraction is the method of choice for tea preparation. The rationale of gamma irradiation is discussed.


Contamination, microbial Drug stability Gamma rays Senna Sennosides Sterilization Tea 


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Copyright information

© Bohn, Scheltema & Holkema 1988

Authors and Affiliations

  • H. Van Doorne
    • 1
  • E. H. Bosch
    • 1
  • J. H. Zwaving
    • 2
  • E. T. Elema
    • 2
  1. 1.Department of Pharmaceutical Technology and BiopharmaceuticsState University of GroningenAW Groningenthe Netherlands
  2. 2.Department of PharmacognosyState University of GroningenAW Groningenthe Netherlands

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