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Pharmaceutisch Weekblad

, Volume 10, Issue 5, pp 213–216 | Cite as

Adsorption of human and porcine insulins to intravenous administration sets

  • A. Tol
  • R. F. P. Quik
  • J. H. H. Thyssen
Short Communications

Abstract

A comparison between human and porcine insulins with regard to their adsorption to administration sets was performed. A125I-mono(A14)-iodinated insulin was used to follow the adsorption phenomenon over time and the adsorption was quantified with radioimmunoassays of unlabelled insulin. The obtained data were similar for both methods. No relevant difference in adsorption was found between human and porcine insulin. Both insulins showed a significantly more pronounced initial drop in delivered insulin when polyethylene tubing was used. After 3 h a steady state was reached, resulting in the administration of a more predictable dose. Particularly in the initial phase an important reduction in the amount of both insulins actually delivered to the patient was observed when compared to the expected amount as calculated from the concentration present in the container and the infusion rate.

Therefore, the mainstay in treatment of a patient with ketoacidosis remains frequent serum glucose measurement and making appropriate infusion rate adjustments on that basis.

Keywords

Adsorption Equipment and supplies Infusions, parenteral Insulin Polyethylenes Polyvinylchloride 

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References

  1. 1.
    Fernbee JW, Johnson BB, Mithoefer JC, Gardella JW. Insulin and adrenocorticotropin labeled with radioiodine. Endocrinology 1951;48:277–83.PubMedGoogle Scholar
  2. 2.
    Hirsch JI, Fratkin MJ, Wood JH, Thomas RB. Clinical significance of insulin adsorption by polyvinylchloride infusion systems. Am J Hosp Pharm 1977;34:583–8.PubMedGoogle Scholar
  3. 3.
    Hirsch JI, Wood JH, Thomas RB. Insulin adsorption to polyolefin infusion bottles and polyvinyl chloride administration sets. Am J Hosp Pharm 1977;38:995–7.Google Scholar
  4. 4.
    Cecil R, Robinson GB. The specific binding of insulin to polythene and other materials. Biochim Biophys Acta 1975;404:164–8.PubMedGoogle Scholar
  5. 5.
    Petty C, Cunningham NL, Major MC. Insulin adsorption by glass infusion bottles, Polyvinylchloride infusion containers and intravenous tubing. Anaesthesiology 1974;40:400–44.Google Scholar
  6. 6.
    Peterson L, Caldwell J, Hoffman J. Insulin adsorbance to polyvinylchloride surfaces with implications for constant-infusion therapy. Diabetes 1976;25:72–4.PubMedGoogle Scholar
  7. 7.
    Allwood MC. Sorption of drugs to intravenous delivery systems. Pharm Int 1983;4:83–5.Google Scholar
  8. 8.
    Twardowski ZJ, Nolph KD, McGary TJ, Moore HJ. Nature of insulin binding to plastic bags. Am J Hosp Pharm 1983;40:579–82.PubMedGoogle Scholar
  9. 9.
    Derksen RHWM, Van de Wiel A, Poortman J, Der Kinderen PJ, Kater L. Plasma-exchange in the treatment of severe thyrotoxicosis in pregnancy. Eur J Obstet Gynecol Reprod Biol 1984;18:139–48.PubMedGoogle Scholar
  10. 10.
    Kristofferson J, Skobba TJ, Johansen R. Adsorption of insulin to infusion equipment. Nor Farm Tidsskr 1977;85:220–4.Google Scholar
  11. 11.
    Weber SS, Wood WA, Jackson EA. Availability of insulin from parenteral nutrient solutions. Am J Hosp Pharm 1977;34:353–7.PubMedGoogle Scholar
  12. 12.
    Kortland W, Thijssen JH Variation among insulin radioimmunoassay is mainly a matter of standardization. Clin Chem 1983;29:1689–90.Google Scholar
  13. 13.
    Tukey JW. One degree of freedom for non-additivity. Biometrics. 1949;5:232–42.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1988

Authors and Affiliations

  • A. Tol
    • 1
  • R. F. P. Quik
    • 2
  • J. H. H. Thyssen
    • 3
  1. 1.Lukas HospitalApeldoornthe Netherlands
  2. 2.Medical DepartmentEli Lilly NetherlandsHA Nieuwegeinthe Netherlands
  3. 3.Academic Hospital UtrechtUtrechtthe Netherlands

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