Pharmaceutisch Weekblad

, Volume 9, Issue 1, pp 24–28 | Cite as

Relations between tablet properties

  • J. A. H. de Jong
Original Articles


With the aid of simple mathematical models the relations between specific crushing strength (i.e. crushing strength divided by the breaking surface), friability and disintegration time of a tablet can be given. The friability is related to the porosity of the tablets and the specific crushing strength, independent of the process conditions. For the disintegration time two models have been used, depending on the disintegration mechanism. In the first one the disintegration time is only dependent on the porosity, in the second on the specific surface by weight of the granules of which the tablets are made. The theoretical relationships were verified for two tablet formulations, made under varying process conditions.

Key words

Crushing-strength Disintegration time Friability Mathematics Porosity Tablets 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1987

Authors and Affiliations

  • J. A. H. de Jong
    • 1
  1. 1.Akzo Corporate Research DepartmentAB ArnhemThe Netherlands

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