On the efficacy of low dose prednisolone and heparin sodium in the prevention of infusion thrombophlebitis. A double-blind trial
A prospective, double-blind investigation into the effectiveness of the addition to infusion fluids of an injectable containing 0.3 mg prednisolone and 10 units heparin per ml in a phosphate buffer pH=7·5 versus the phosphate buffer alone is described. 196 Patients were allocated alternately to each group. On a total number of 593 cannulation days, 16 cases of thrombophlebitis were diagnosed. Statistical evaluation revealed a significant difference between the two groups (p<0.01) in favour of prednisolone + heparin sodium.
KeywordsPublic Health Sodium Phosphate Internal Medicine Phosphate Buffer
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Elfving G, Hästbacka J. Infusion thrombophlebitis and its prevention. Am Heart J 1967;73:717–8.CrossRefPubMedGoogle Scholar
Hoshal VL, Ause RG, Hokins PA. Fibrin sleeve formation on indwelling central venous catheters. Arch Surg 1971;102:353–8.Google Scholar
Henzel JH, De Weese MS. Morbid and mortal complications associated with prolonged central venous cannulation. Am J Surg 1971;121:600–5.CrossRefPubMedGoogle Scholar
Maki DG, Goldman DA, Rhane FS. Infection control in intravenous therapy. Ann Intern Med 1973;79:867–86.PubMedGoogle Scholar
Hop WCJ, Hermans J. Statistische analyse van overlevingsduren. Tijdschr Soc Geneeskd 1981;59:279–88.Google Scholar
Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer 1977;35:1–35.PubMedGoogle Scholar
© Royal Dutch Association for Advancement of Pharmacy 1984