Pharmacy World and Science

, Volume 15, Issue 4, pp 173–175 | Cite as

Intramuscular and subcutaneous drug delivery: Encapsulation in liposomes and other methods to manipulate drug availability

  • F. Kadir
Doctoral Theses


Biological availability Drug administration routes Drug stability Lipophilicity Liposomes 


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Results have also been published in the following papers

  1. Kadir F, Zuidema J. A high performance liquid chromatographic method for determination of carazolol in serum or plasma of pigs. J Chromatogr Biomed Appl 1990;527:461–6.CrossRefGoogle Scholar
  2. Kadir F, Pijpers A, Vulto A, Verheijden JMH. Drug lipophilicity and release pattern of someβ-blocking agents after intraadipose injection in pigs. Int J Pharm 1990;64:171–80.CrossRefGoogle Scholar
  3. Kadir F, Zuidema J, Pijpers A, Melendez R, Vulto A, Verheijden JMH. Pharmacokinetics of intravenously, intramuscularly and intra-adiposely administered carazolol in pigs. J Vet Pharmacol Ther 1990; 13:350–5.PubMedCrossRefGoogle Scholar
  4. Kadir F, Eling WMC, Crommelin DJA, Zuidema J. Influence of injection volume on the release kinetics of liposomal chloroquine administered subcutaneously or intramuscularly to mice. J Controlled Rel 1991;17:277–84.CrossRefGoogle Scholar
  5. Kadir F, Eling WMC, Crommelin DJA, Zuidema J. Kinetics and prophylactic efficacy of increasing dosages of liposomeencapsulated chloroquine after intramuscular injection into mice. J Controlled Rel 1992;20:47–54.CrossRefGoogle Scholar
  6. Kadir F, Scijsener CBJ, Zuidema J. Influence of the injection volume on the release pattern of intramuscularly injected propranolol to rats. Int J Pharm 1992;81:193–8.CrossRefGoogle Scholar
  7. Kadir F, Zuidema J, Crommelin DJA. Liposomes as drug delivery systems for intramuscular and subcutaneous injections. In: Rolland A, editor. Particulate drug carriers in medical application. New York: Marcel Dekker. In press.Google Scholar
  8. Kadir F, Eling WMC, Abrahams D, Zuidema J, Crommelin DJA. Tissue reaction after intramuscular injection of liposomes in mice. Int J Clin Pharmacol Ther Toxicol 1992;30(10):374–82.PubMedGoogle Scholar

Copyright information

© Periodicals Service Company 1993

Authors and Affiliations

  • F. Kadir
    • 1
  1. 1.Faculty of PharmacyUtrecht UniversityTB UtrechtThe Netherlands

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