Advertisement

Pharmacy World and Science

, Volume 16, Issue 3, pp 164–166 | Cite as

Bioanalysis and pharmacokinetics of (investigational) vinca alkaloids

  • Olaf van Tellingen
Doctoral Theses
  • 42 Downloads

Keywords

Chromatography, high pressure liquid Pharmacokinetics Vinca alkaloids 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Results have also been published in the following papers

  1. van Tellingen O, van der Woude HR, Beijnen JH, Bushana Rao KSP, ten Bokkel Huinink WW, Nooijen WJ. High-performance liquid Chromatographic bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug vintriptol. J Chromatogr 1990;529:329–38.PubMedGoogle Scholar
  2. van Tellingen O, Beijnen JH, van der Woude HR, Baurain R, ten Bokkel Huinink WW, Nooijen WJ. Bio-analysis ofN-(deacetyl-O-4-vinblastoyl-23)-L isoleucinate methane sulphonate (VileE) by high-performance liquid chromatography with fluorescence detection. J Pharm Biomed Anal 1990;8:1029–31.PubMedGoogle Scholar
  3. van Tellingen O, Beijnen JH, Baurain R, ten Bokkel Huinink WW, van der Woude HR, Nooijen WJ. High-performance liquid Chromatographic determination of vinblastine, 4-O-deacetylvinblastine and the potential metabolite 4-O-deacetylvinblastine-3-oic acid in biological fluids. J Chromatogr 1991;553:47–53.PubMedGoogle Scholar
  4. van Tellingen O, Beijnen JH, Nooijen WJ. Analytical methods for the determination of vinca alkaloids in biological specimens: a survey of the literature. J Pharm Biomed Anal 1991;9:1077–82.PubMedGoogle Scholar
  5. Oosterkamp HM, Vlasveld LT, Wanders J, Beijnen JH, van Tellingen O, Dubbelman AC, et al. Phase I study of vintriptol, a tryptophan ester of vinblastine. Eur J Cancer 1991;27:1222–6.PubMedGoogle Scholar
  6. van Tellingen O, Kuijpers AV, Beijnen JH, Baselier MRP, Burghouts JTM, Nooijen WJ. Bio-analysis of vinorelbine by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1992;573:328–32.PubMedGoogle Scholar
  7. van Tellingen O, Beijnen JH, Baurain R, ten Bokkel Huinink WW, van der Woude HR, Nooijen WJ. Biodetermination ofN-(deacetyl-O-4-vinblastoyl-23)-L tryptophan, a metabolite of vintriptol, by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1992;574:293–8.PubMedGoogle Scholar
  8. van Tellingen O, Beijnen JH, Nooijen WJ, Bult A. Pharmacology, bio-analysis and pharmacokinetics of the vinca alkaloids and semi-synthetic derivatives (review). Anticancer Res 1992;12:1699–715.PubMedGoogle Scholar
  9. van Tellingen O, Beijnen JH, Nooijen WJ, Bult A. Plasma pharmacokinetics of vinblastine and the investigational vinca alkaloidN-(deacetyl-O-4-vinblastoyl-23)-L isoleucinate in mice as determined by high-performance liquid chromatography. Cancer Res 1993;53:2061–5.PubMedGoogle Scholar
  10. van Tellingen O, Beijnen JH, Nooijen WJ, Bult A. Plasma pharmacokinetics, disposition excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography. Cancer Chemother Pharmacol 1993;32:286–92.PubMedGoogle Scholar
  11. van Tellingen O, Kuijpers AV, Beijnen JH, Nooijen WJ, Bult A. Plasma pharmacokinetics, disposition excretion and metabolism of vinorelbine in mice as determined by high-performance liquid chromatography. Invest New Drugs 1993;11:141–50.PubMedGoogle Scholar
  12. van Tellingen O, Sonneveldt ALC, Beijnen JH, Nooijen WJ, Kettenes-van den Bosch JJ, Versluis C, et al. Plasma pharmacokinetics, disposition excretion and metabolism of vinleucinol in mice as determined by high-performance liquid chromatography. Cancer Chemother Pharmacol 1994;33:423–34.Google Scholar

Copyright information

© Royal Dutch Association for the Advancement of Pharmacy 1994

Authors and Affiliations

  • Olaf van Tellingen
    • 1
    • 2
  1. 1.Utrecht UniversityUtrecht
  2. 2.Department of Clinical ChemistryAntoni van Leeuwenhock Huis/The Netherlands Cancer InstituteCX Amsterdamthe Netherlands

Personalised recommendations