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Pharmacy World and Science

, Volume 17, Issue 2, pp 31–41 | Cite as

Corticosteroid receptor antagonists: A current perspective

  • Win Sutanto
  • E. Ronald de Kloet
Reviews

Abstract

This review aims to highlight a selection of antagonists for the mineralocorticoid and glucocorticoid receptors. Concepts of these receptor systems are described, as is the mechanism of action of these steroids in the brain and periphery. Examples of commonly available and newly synthesized antimineralocorticoids and antiglucocorticoids are given, together with their pharmacological profiles and, when appropriate, clinical and therapeutic applications.

Keywords

Adrenal cortex hormones Drug development Glucocorticoids Mifepristone Mineralocorticoids Pharmacology Receptors, steroid Steroid receptor antagonists 
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© Royal Dutch Association for Advancement of Pharmacy 1995

Authors and Affiliations

  • Win Sutanto
    • 1
  • E. Ronald de Kloet
    • 2
  1. 1.Divisions of Pharmacology and Medical PharmacologyCentre for Bio-Pharmaceutical Sciences Sylvius LaboratoriesRA Leidenthe Netherlands
  2. 2.Division of Medical PharmacologyCentre for Bio-Pharmaceutical SciencesLeidenthe Netherlands

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