Advertisement

Pharmacy World and Science

, Volume 16, Issue 4, pp 181–186 | Cite as

Drug utilization review of oral forms of benzodiazepines in a Belgian 635-bed teaching hospital

  • N. Petit
  • J. -P. Delporte
  • M. Ansseau
  • A. Albert
  • F. Jeusette
Articles

Abstract

A retrospective study based on 4,307 drug patient records was designed to establish a chart of the consumption of benzodiazepines administered orally in a 635-bed teaching hospital, and to determine the influence of patient-related parameters (age, sex) and hospital-related parameters (type of services, prescription habits,etc.) on benzodiazepine Utilization. Another objective was to evaluate to which extent benzodiazepine consumption can be induced by hospitalization. A minor but statistically significant difference (p <0.05) was observed between the proportion of male (42.7%) and female (46.5%) users. Besides, when evaluating the consumption in number of defined daily doses per 100 beddays, there was little difference between the consumption of male (51.2 defined daily doses per 100 beddays) and female (52.8 defined daily doses per 100 beddays) patients. A significant influence of age was also observed with an increase of benzodiazepine use for patients aged from 15–20 to 40–45, followed by a progressive decrease for higher ages. With hypnotics, no peak of consumption related to age was observed but an increase of consumption from age 15–20 to 30–35. For higher ages the consumption of hypnotics was nearly stable or rising slowly. High variations in benzodiazepine utilization were recorded between hospital wards (median: 50.77 defined daily doses per 100 beddays, range 0.23–263.9). Finally, it was found that 6.8% of patients with a benzodiazepine treatment initiated during hospitalization may be considered as potential benzodiazepine consumers after discharge.

Keywords

Benzodiazepines Data collection Drug utilization Hospitals Prescription, drugs 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Balter MB, Manheimer DI, Mellinger D, Uhlenhuth EH. A cross-national comparison of anti-anxiety per sedative drug use. Curr Med Res Opin 1984;8 Suppl 4:5–20.PubMedGoogle Scholar
  2. 2.
    Ansseau M. The pharmacological treatment of anxiety. Rev Med Liege 1988;43:80–91.PubMedGoogle Scholar
  3. 3.
    Le Goc I, Feline A, Frebault D, Le Bras P, Caquet R. Characteristics of benzodiazepine consumption in a Department of Internal-Medecine. Encephale 1985;11:1–6.PubMedGoogle Scholar
  4. 4.
    Ruiz I, Offermanns J, Fuentes P, Castillo M. Utilization of benzodiazepines in Chile during 1982–1986. Eur J Clin Pharmacol 1989;37:139–43.PubMedGoogle Scholar
  5. 5.
    Fleischhacker W, Barnas C, Stuppack C. Benzodiazepines: utilization and patterns of use in a university hospital. Pharmacopsychiatry 1989;22:111–4.Google Scholar
  6. 6.
    Shan K, Nolan JA, Turner P, Jackson S. Prescription of benzodiazepines in a London teaching hospital. J R Soc Med 1990;83:306–7.PubMedGoogle Scholar
  7. 7.
    Edwards C, Bushnell JL, Ashton CH, Rawlins MD. Hospital prescribing and usage of hypnotics and anxiolytics. Br J Clin Pharmacol 1991;31:190–2.PubMedGoogle Scholar
  8. 8.
    Surendrakumar D, Dunn M, Roberts CJC. Hospital admission and the start of benzodiazepine use. BMJ 1992;304:881.PubMedGoogle Scholar
  9. 9.
    Vandel S, Nezelof S, Bonin B, Dominique Mesnage A, Bertschy G, Jacquet M, et al. Consumption of benzodiazepines in a university hospital centre. Encephale 1992; 18:401–5.PubMedGoogle Scholar
  10. 10.
    Anatomical Therapeutic Chemical (ATC) Classification Index including Defined Daily Doses (DDDs) for plain substances. Oslo: World Health Organization, 1993.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1994

Authors and Affiliations

  • N. Petit
    • 1
  • J. -P. Delporte
    • 1
  • M. Ansseau
    • 2
  • A. Albert
    • 3
  • F. Jeusette
    • 3
  1. 1.Department of PharmacyUniversity HospitalLiègeBelgium
  2. 2.Department of PsychiatryUniversity HospitalLiège
  3. 3.Department of Medical StatisticsUniversity HospitalLiège

Personalised recommendations