Pharmacy World and Science

, Volume 16, Issue 5, pp 225–230 | Cite as

Analysis of total parenteral nutrition utilization in intensive-care patients

  • Ellen Frankfort
  • Cees Zimmerman
  • George F. Borm
  • Roelof van Dalen
  • Yechiel A. Hekster


The objective of this study is to validate an all-in-one defined daily dose (DDD) methodology for studying the utilization of total parenteral nutrition (TPN) with patient-linked data. Furthermore, the utilization of TPN in intensive-care patients is described. In a prospective survey, conducted from March to August 1992 on two intensive-care units, 47 patients using TPN were followed. Adapted ratios of prescribed daily dose (PDD) and DDD for amino acids, fat emulsion, and carbohydrates were 0.76±0.22, 0.69±0.30 and 1.07±0.23 (mean±SD), respectively. The ratio of the number of TPN DDD's to the number of TPN treatment days was 0.84±0.18. The prescription rate of TPN was 19.9 DDD/100 beddays, composed of 5.9 DDD/100 beddays for amino acids, 5.8 for fat emulsion, and 8.2 (or carbohydrates. It was shown that the proposed all-in-one DDD methodology can be used to describe the utilization of TPN and its components. The DDD's for amino acids, fat emulsion, and carbohydrates are valid for use in intensive-care patients.


Amino acids Carbohydrates Data collection Defined daily dose Drug utilization Fats Parenteral feeding 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1994

Authors and Affiliations

  • Ellen Frankfort
    • 1
  • Cees Zimmerman
    • 2
  • George F. Borm
    • 3
  • Roelof van Dalen
    • 2
  • Yechiel A. Hekster
    • 1
  1. 1.Department of Clinical PharmacyUniversity Hospital NijmegenHB Nijmegenthe Netherlands
  2. 2.Department of Intensive CareUniversity Hospital NijmegenNetherlands
  3. 3.Department of Medical StatisticsUniversity Hospital NijmegenNetherlands

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