Abstract
To verify that variations caused by total parenteral nutrition (TPN) in O2 intake (VO2) and CO2 output (VCO2) can affect respiratory function of non-hypercatabolic patients, we studied 18 patients in two groups; group I (control): eight patients receiving 75–100g glucose/24 h, and group II: ten patients fed intravenously on 13.6 g N2 and approximately 2,800 kcal/24 h given as a) 62% glucose+38% fats (TPN-G+F) and b) 100% glucose (TPN-G). VO2, VCO2, respiratory quotient (RQ) and minute ventilation (VE) were measured in all patients. We found that VCO2 was 27% higher in intravenously fed patients (p<0.01 andp<0.02). similarly, VE was 26% higher in intravenously fed patients (p<0.001 andp<0.02). Comparison of TPN-G+F and TPN-G results showed no differences in VCO2; by contrast, VO2 was 21% less during TPN-G(p<0.01).
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References
Askanazi J, Carpentier YA, Elwyn DH, Nordenstron J, Jeevenandam M, Rosenbaum SH, Gump FE, Kinney JM (1980) Influence of total parenteral nutrition on fuel utilization in injury and sepsis. Ann Surg 191:40–46
Askanazi J, Nordenstrom J, Rosenbaum SH, Elwyn DH, Hyman AI, Carpentier YA, Kinney JM (1981) Nutrition for the patient with respiratory failure: glucose vs fats. Anesthesiology 54:373–377
Askanazi J, Rosenbaum SH, Himan AI, Silverberg PA, Milic-Emili J, Kinney JM (1980) Respiratory changes induced by the large glucose load of total parenteral nutrition. J Am Med Assoc 243:1444–1447
Cantarow A, Schepartz B (1969) Metabolismo energetico. In: Bioquimica, 4th edn. Interamericana, Mexico, pp 326–327
Gieseke T, Gurushantaiah G, Glauser F (1977) Effects of carbohydrates on carbon dioxide excretion in patients with airway disease. Chest 71:55–58
Kinney JM (1979) Energy flow, a vital theme in injury and infection. In: Wahrem J (ed) 1st European congress on parenteral and enteral nutrition. Acta Chir Scand, Suppl 498:20–25
Kinney JM, Long CL, Gump FE, Duke JH (1968) Tissue composition of weight loss in surgical patients I. Ann Surg 168:459–474
Knoebel LK (1971) Metabolismo energetico. In: Selkurt EE (ed) Fisiologia. El Ateneo, Buenos Aires, pp 598–612
Reid DJ (1967) Intravenous fat therapy II. Br J Surg 54:204–207
Saltzman HA, Salzano JV (1971) Effects of carbohydrate metabolism upon respiratory gas exchange in normal men. J Appl Physiol 30:228–231
Tremolieres J (1969) Metabolisme calorique. In: Glandes endocrines et nutrition II, Encyclopédie médico chirurgicale. Éditions Techniques et Scientifiques Françaises, Paris 10503 A10
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Fernandez Mondejar, E., Duro Lombardo, M., Perez de la Cruz, A.J. et al. Variations in oxygen consumption and carbon dioxide production during parenteral nutrition. Intensive Care Med 8, 169–172 (1982). https://doi.org/10.1007/BF01725733
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DOI: https://doi.org/10.1007/BF01725733