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Vitamin D status after total gastrectomy

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Abstract

Serum levels of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D, immunoreactive parathyroid hormone, and urinary excretion of nephrogenous cyclic AMP were measured in 25 patients after total gastrectomy. Two types of reconstruction after total gastrectomy were also compared. Serum 25-hydroxyvitamin D levels were significantly decreased and serum 24,25-dihydroxyvitamin D levels were markedly reduced, whereas serum 1,25-dihydroxyvitamin D levels were significantly increased in the patients. Although serum levels of immunoreactive parathyroid hormone did not show a significant difference, serum alkaline phosphatase levels and urinary excretion of nephrogenous cyclic AMP were significantly increased in the patients. The results suggest that defective vitamin D storage and enhanced vitamin D action coexist in patients after total gastrectomy and that the enhanced vitamin D action, possibly derived from slightly increased parathyroid function, would be a compensatory mechanism to sustained calcium deficiency. No substantial difference of vitamin D status was observed between the two types of reconstruction which differed in passage through the duodenum.

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Authors and Affiliations

  1. First Department of Surgery, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113

    Kunihisa Kozawa MD, Michio Imawari MD, Hisaaki Shimazu MD, Oichiro Kobori MD, Toshiaki Osuga MD & Yasuhiko Morioka MD

  2. Department of Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

    Kunihisa Kozawa MD, Michio Imawari MD, Hisaaki Shimazu MD, Oichiro Kobori MD, Toshiaki Osuga MD & Yasuhiko Morioka MD

Authors
  1. Kunihisa Kozawa MD
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  2. Michio Imawari MD
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  3. Hisaaki Shimazu MD
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  4. Oichiro Kobori MD
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  5. Toshiaki Osuga MD
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  6. Yasuhiko Morioka MD
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Additional information

This study was supported in part by a research grant from the Intractable Diseases Division, Public Health Bureau, Ministry of Health and Welfare, Japan, and in part by a grant from Chugai Pharmaceutical Company, Tokyo, Japan.

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Kozawa, K., Imawari, M., Shimazu, H. et al. Vitamin D status after total gastrectomy. Digest Dis Sci 29, 411–416 (1984). https://doi.org/10.1007/BF01296215

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  • DOI: https://doi.org/10.1007/BF01296215

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