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Acta neurovegetativa

, Volume 25, Issue 4, pp 560–563 | Cite as

The effect of su-4885 on the hypothalamo-hypophyseal neurosecretory system of the rat

  • A. Eisalo
  • M. Viranko
  • S. Talanti
Article
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Summary

The effect of Su-4885 on the hypothalamo-hypophyseal neurosecretory system of the rat was studied by histological means. No changes in the amount of the neurosecretory material or in the activity of the neurosecretory ganglion cells could be observed. It was concluded that the release of ACTH and the activity of the hypothalamo-hypophyseal system do not go in parallel.

Keywords

Public Health Ganglion Cell Neurosecretory System Neurosecretory Material 

Zusammenfassung

Die Wirkung von Su-4885 auf das hypothalamo-hypophysäre neurosekretorische System der Ratte wurde mit histologischen Methoden untersucht. Die Neurosekretfärbbarkeit des ganzen Systems blieb erhalten und Änderungen in der Aktivität der neurosekretorischen Ganglienzellen konnten nicht beobachtet werden. Hierbei wurde festgestellt, daß die Absonderung von ACTH nicht parallel zur Aktivität des hypothalamo-hypophysären neurosekretorischen Systems auftritt.

Résumé

L'effet du Su-4885 sur le système neurosécrétoire au niveau du complexe hypothalamo-hypophysaire chez le rat fut étudié par méthodes histologiques. Aucun changement de la quantité de substances neurosécrétées et de l'activité des cellules ganglionnaires neurosécrétoires fut observée. On peut donc conclure que le drainage de l'ACTH n'est pas paralléle à l'activité du système neurosécrétoire au niveau du complexe hypothalamo-hypophysaire.

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References

  1. Cavallero, C., E. Dova andL. Rossi, Antidiuretic activity in the neurohypophysis of rats after adrenalectomy and replacement therapy. J. Endocr.10 (1954), 228.CrossRefGoogle Scholar
  2. Guillemin, R., Hypothalamic-Hypophysial Interrelationships. Springfield, Illinois, 1956.Google Scholar
  3. Harris, G. W., Neural Control of the Pituitary Gland. London, 1955.Google Scholar
  4. Kahnt, F. W., andR. Neher, On the specific inhibition of adrenal steroid biosynthesis. Experientia, Basel,18 (1962), 499.CrossRefGoogle Scholar
  5. Landing, B. H., H. E. Hall andC. D. West, Aldehyde-fuchsin positive material of the posterior pituitary. Laborat. Invest.5 (1956), 256.PubMedGoogle Scholar
  6. Mirsky, I. A., M. Stein andG. Paulisch, The secretion of an antidiuretic substance into the circulation of rats exposed to noxious stimuli. Endocrinology54 (1954), 491.CrossRefGoogle Scholar
  7. Porter.J. C., andJ. C. Jones, Effect of plasma from hypophyseal portal vessel blood on adrenal ascorbic acid. Endocrinology58 (1956), 62.CrossRefGoogle Scholar
  8. Rinne, U. K., Neurosecretory material around the hypophysial portal vessels in the median eminence of the rat. Acta endocr.35, Suppl. 57 (1960), 1.PubMedGoogle Scholar
  9. Rinne, U. K., E. Kivalo andK. Lahtinen, Studies on the corticotrophin releasing activity of synthetic oxytocin. Acta endocr.32 (1959), 589.CrossRefGoogle Scholar
  10. Rothballer, A. B., Changes in the rat neurohypophysis induced with painful stimuli with particular reference to neurosecretory material. Anat. Rec., Philadelphia,115 (1953), 21.CrossRefGoogle Scholar
  11. Saffran, M., A. V. Schally, M. Segal andB. Zimmermann, Zweites Internationales Symposium über Neurosekretion. Berlin-Göttingen-Heidelberg, 1958.Google Scholar
  12. Smelik, P. G., Autonomic Nervous Involvement in Stress-Induced ACTH Secretion. Assen, 1959.Google Scholar
  13. Winter, L., H. L. Hollings andR. B. Stebbing, The effect of androgenic hormones upon the adrenal atrophy produced by cortisone injections and upon the anti-inflammatory action of cortisone. Endocrinology52 (1953), 123.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1964

Authors and Affiliations

  • A. Eisalo
    • 1
  • M. Viranko
    • 1
  • S. Talanti
    • 1
  1. 1.Department of Anatomy and EmbryologyCollege of Veterinary MedicineHelsinkiFinland

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