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Documenta Ophthalmologica

, Volume 26, Issue 1, pp 324–333 | Cite as

The reversal of triparanol induced cataracts in the rat

  • John E. Harris
  • Louise Gruber
Article

Summary

Weanling rats were fed a diet containing 0.075% triparanol for 67 days and then returned to a normal diet. All lenses eventually developed a dense central opacity with a peripheral zone of varying degrees of opacity. The onset of the central opacity was generally quite abrupt and was accompanied by a marked increase in sodium and water but with little change in potassium. As the animals were continued on a regular diet the opacities tended to clear and the sodium content and water decreased to essentially normal levels.

Keywords

Cataract Normal Diet Sodium Content Dense Nucleus Kalium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

De jeunes rats ont reçu pendant 67 jours une nourriture contenant 0,075% de triparanol, puis on les a remis à un régime normal. Dans tous les cristallins on a vu se développer finalement une opacité centrale très dense entourée d'une zone périphérique plus ou moins opaque. Le début de la cataracte centrale était en général brusque et s'accompagnait d'un enrichissement marqué en sodium et en eau, alors que la teneur en potassium ne changeait guère. Après le retour à un régime normal les lentilles ont eu tendance à s'éclaircir et les taux du sodium et de l'eau ont diminué pour revenir partiquement à un niveau normal.

Zusammenfassung

Junge Ratten erhielten während 67 Tagen eine 0.075% Triparanol enthaltende Nahrung, um nachher zu einer normalen Diät zurückzukehren. In sämtlichen Linsen erschien schließlich eine dichte zentrale Trübung, welche von einer peripheren Zone mit mehr oder weniger ausgeprägten Katarakten umgeben war. Im allgemeinen trat der Zentralstar sehr plötzlich auf und dieser Vorgang war mit einer Erhöhung des Natrium- und Wassergehaltes verbunden, während das Kalium sich kaum veränderte. Nach der Rückkehr zur normalen Ernährung war eine gewisse Aufhellung der Linsen festzustellen; auch fielen die Natrium- und Wasserwerte, bis sie praktisch wieder normal waren.

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Copyright information

© Dr. W. Junk N.V. 1969

Authors and Affiliations

  • John E. Harris
    • 1
  • Louise Gruber
    • 1
  1. 1.Department of OphthalmologyUniversity of MinnesotaUSA

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