Documenta Ophthalmologica

, Volume 26, Issue 1, pp 61–72 | Cite as

Fluorescein dynamics in the eye

  • Jose Cunha-Vaz
  • David Maurice


Fluorescein injected into the vitreous body is transported rapidly out of the eye in the posterior segment. Injected in excess or in the presence of competitive inhibitors it leaves more slowly, by way of the anterior chamber. Systemically administered fluorescein reaches higher levels in the anterior chamber when inhibitors are acting on the eye. Direct observation shows that the concentration in the newly secreted aqueous humour also is increased.


Fluorescein Anterior Chamber Aqueous Humour Ciliary Body Vitreous Body 
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La fluorescéine injectée dans le corps vitré est transportée rapidement hors de l'oeil par la voie postérieure. Lorsque l'injection se fait avec un excès en fluorescéine ou en présence d'inhibiteurs compétitifs, la sortie est plus lente et le colorant passe par la chambre antérieure. Après une injection intrapéritonéale ou intraveineuse la fluorescéine atteint des taux plus élevés dans la chambre antérieure, lorsque des inhibiteurs agissent sur l'oeil. L'observation directe montre que la concentration est également augmentée dans l'humeur aqueuse nouvellement sécrétée.


In den Glaskörper injiziertes Fluoreszein wird schnell durch die hinteren Abschnitte aus dem Auge transportiert. Wenn es im Übermaß oder in Gegenwart konkurrierender Hemmstoffe injiziert wird, verläßt es das Auge langsamer durch die Vorderkammer. In den Körper eingeführtes Fluoreszein ergibt ein höheres Niveau in der vorderen Kammer, wenn Hemmstoffe auf das Auge wirken. Direkte Beobachtung zeigt, daß die Konzentration auch im frisch sezernierten Kammerwasser erhöht ist.


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Copyright information

© Dr. W. Junk N.V. 1969

Authors and Affiliations

  • Jose Cunha-Vaz
    • 1
    • 3
    • 4
  • David Maurice
    • 1
    • 2
    • 3
    • 4
  1. 1.Instituto de Alta Cultura & Institute of OphthalmologyLondonUK
  2. 2.Division of OphthalmologyStanford University Medical CenterStanfordUSA
  3. 3.LisbonUSA
  4. 4.Los AltosUSA

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