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The rostral zone of the intermediate lobe of the mouse hypophysis, a zone of particular concentration of corticotrophic cells

A light and electron microscopic study


The rostral zone of the intermediate lobe of the mouse hypophysis can clearly be distinguished from the other lobes of the adenohypophysis, especially from the pars tuberalis and the remainder of the intermediate lobe. It consists almost exclusively of corticotrophic cells which show reactive changes after adrenalectomy. The hypophysial stalk is entirely surrounded by this zone; laterally it forms large cell aggregations which extend dorsally as thin cell strands. The corticotrophs are also found within the hypophysial stalk which they invade along the blood vessels; frequently they are dispersed among the typical cells of the intermediate lobe, especially along the neural lobe and the hypophysial cleft.

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  1. Bargmann, W., Lindner, E., Andres, K. H.: Über Synapsen an endokrinen Epithelzellen und die Definition sekretorischer Neurone. Untersuchungen am Zwischenlappen der Katzenhypophyse. Z. Zellforsch.77, 282–289 (1967).

  2. Engelhardt, F.: Zur Morphologie des Hypophysenzwischenlappens im Experiment. 8. Symp. deutsch. Ges. Endokrinol. München 1961, S. 159–186. Berlin-Göttingen-Heidelberg: Springer 1962.

  3. Lothringer, S.: Untersuchungen an der Hypophyse einiger Säugetiere und des Menschen. Arch. mikr. Anat.28, 257–292 (1886).

  4. Mialhe, C., Koch, B.: Etude biologique comparée des hormones corticotropes. In: La spécifité zoologique des hormones hypophysaires et de leurs activités (Paris, 1968). Colloques internationaux du C.N.R.S. n∘ 177. Editions du C.N.R.S. (1969).

  5. Mialhe-Voloss, C.: Post-hypophyse et activité corticotrope. Acta endocr. (Kbh.), Suppl.35, 1–96 (1958).

  6. Porte, A., Klein, M. J., Stoeckel, M. E., Stutinsky, F.: Sur l'existence de cellules de type “corticotrope” dans la pars intermedia de l'hypophyse du rat. Etude au microscope électronique. Z. Zellforsch.115, 60–68 (1971).

  7. Romeis, B.: Innersekretorische Drüsen. II. Hypophyse. In: Handbuch der mikroskopischen Anatomie des Menschen, hrsg. von W. von Möllendorff, Bd. VI/3. Berlin: Springer 1940.

  8. Stoeckel, M. E., Porte, A.: Localisation ultimobranchiale et thyroidienne des cellules C (cellules à calcitonine) chez deux Columbidae: le pigeon et le tourtereau. Etude au microscope électronique. Z. Zellforsch.102, 376–386 (1969).

  9. Watari, N.: Fine structure of nervous elements in the pancreas of some vertebrates. Z. Zellforsch.85, 291–314 (1968).

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On leave from the Department of Veterinary Anatomy, University of Missouri, Columbia, Mo., U.S.A.

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Stoeckel, M.E., Dellmann, H.-., Porte, A. et al. The rostral zone of the intermediate lobe of the mouse hypophysis, a zone of particular concentration of corticotrophic cells. Z.Zellforsch 122, 310–322 (1971).

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  • Hypophysis
  • Mouse
  • Rostral zone
  • Intermediate lobe
  • Corticotrophic cells
  • Ultrastructure