Springer Nature is making SARS-CoV-2 and COVID-19 research free View research | View latest news | Sign up for updates

tRNA-rRNA sequence homologies: A model for the origin of a common ancestral molecule, and prospects for its reconstruction

  • 36 Accesses

  • 37 Citations

Abstract

A model is proposed for the early evolution of the coding mechanism. A primordial RNA embodies the functions of today's nucleic acids in a single molecule. The molecule is generated by successive rounds of self-priming and-templating. After proximity is assured by enclosure in a cell, the functions can be partitioned among more efficient specializel molecules. The prediction of sequence homologies in later forms prompted a search for matches between t- and r-RNAs. These are described. Their distributions offer clues to their origins. The existance of overlapping homologies indicates an approach to the reconstruction of an ancestral molecule.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Eigen, M. and Winkler-Oswatitsch, R. 1981. Naturwiss. 68, pp. 282–292.

  2. 2.

    Bloch, D.P., McArthur, B., Widdowson, R., Spector, D., Guimaraes, R.C. and Smith, J. 1982, J. Cell Biol. 95, p. 468.

  3. 3.

    ibid. 1983. J. Mol. Evol. In press.

  4. 4.

    Sprinzl, M. and Gauss, D.H. 1982. Nucleic Acids Res. 10, pp. 1–55.

  5. 5.

    Zweib, C., Glotz, C. and Brimacombe, R. 1981. Nucleic Acid Res. 9, pp. 3621–3640.

  6. 6.

    Goad, W. and Kanehisa, M.I. 1982. Nucleic Acid Res. 10, pp. 247–263.

  7. 7.

    Noller, H.F. and Woese, C.R. 1981. Science 212, pp. 403–411.

  8. 8.

    Woese, C.R., personal communication.

  9. 9.

    Anderson, S., DeBruijn, M.H.L., Coulson, A.R., Eperon, I.C., Sanger, F. and Young, I.G. 1982. J. Mol. Biol. 156, pp. 683–717.

  10. 10.

    Sharp, S., DeFranco, Dingerman, T., Farrell, P. and Soll, D. 1981. Proc. Nat. Acad. Sci. (U.S.A.) 78, pp. 6657–6661.

  11. 11.

    Fitch, W.M. 1970. Syst. Zool. 19, pp. 99–113.

  12. 12.

    Farrelly, F., and Butow, R.A. 1983. Nature 301, pp. 297–301.

  13. 13.

    Bloch, D.P., McArthur, B., Guimaraes, R.C. and Smith, J. Manuscript in preparation.

  14. 14.

    Miller, S.L. and Orgel, L.E. 1974. “The Origin of Life on Earth” Prentice-Hall, Englewood Cliffs, N.J.

  15. 15.

    Wolfenden, R.V., Cullis, P.M. and Southgate, C.C.F., 1979. Science 206, pp. 575–577.

  16. 16.

    Goulian, M.J., Lucas, L., Kornberg, A. 1968. J. Biol. Chem. 243, 627–638.

  17. 17.

    Mackinlay, A.G. 1982. Origin of Life, 12, pp. 55–69.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bloch, D., McArthur, B., Widdowson, R. et al. tRNA-rRNA sequence homologies: A model for the origin of a common ancestral molecule, and prospects for its reconstruction. Origins Life Evol Biosphere 14, 571–578 (1984). https://doi.org/10.1007/BF00933706

Download citation

Keywords

  • Organic Chemistry
  • Nucleic Acid
  • Geochemistry
  • Assure
  • Sequence Homology