A model is proposed for the early evolution of the coding mechanism. A primordial RNA embodies the functions of today's nucleic acids in a single molecule. The molecule is generated by successive rounds of self-priming and-templating. After proximity is assured by enclosure in a cell, the functions can be partitioned among more efficient specializel molecules. The prediction of sequence homologies in later forms prompted a search for matches between t- and r-RNAs. These are described. Their distributions offer clues to their origins. The existance of overlapping homologies indicates an approach to the reconstruction of an ancestral molecule.
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Bloch, D., McArthur, B., Widdowson, R. et al. tRNA-rRNA sequence homologies: A model for the origin of a common ancestral molecule, and prospects for its reconstruction. Origins Life Evol Biosphere 14, 571–578 (1984). https://doi.org/10.1007/BF00933706
- Organic Chemistry
- Nucleic Acid
- Sequence Homology