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Trypanosoma brucei is protected from the cytostatic effects of nitric oxide under in vivo conditions


In mice infected withTrypanosoma brucei, splenic and peritoneal macrophages release substantial amounts of nitric oxide (NO). The production of NO by activated macrophages has been reported to be a nonspecific immune-effector mechansism against several parasites, and in this work we investigate the role of NO in killingT. brucei. Addition of bloodstream trypanosomes to peritoneal macrophages activated in vitro resulted in an NO-dependent inhibition of parasite growth. This effect was totally abrogated when dilutions of whole blood were included in the cultures, suggesting that bloodstream parasites such asT. brucei are not susceptible to NO-mediated killing in vivo.

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Correspondence to J. M. Sternberg.

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Mabbott, N.A., Sutherland, I.A. & Sternberg, J.M. Trypanosoma brucei is protected from the cytostatic effects of nitric oxide under in vivo conditions. Parasitol Res 80, 687–690 (1994). https://doi.org/10.1007/BF00932954

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  • Oxide
  • Nitric Oxide
  • Peritoneal Macrophage
  • Trypanosoma
  • Parasite Growth