Aminopeptidase activity on β-naphthylamide (NA) substrates was assayed in brain extracts from normal andToxoplasma gondii-infected mice at 4 months postinfection. Correlations of levels of aminopeptidase activity,Toxoplasma-specific antibody production, and the number of brain cysts were studied in normal andToxoplasma-infected mice. TheToxoplasma-specific antibody and the formation of cysts were markedly enhanced in the parasite-infected mice. The highest levels of activity for the NA substrates tested were observed in normal mice. In contrast, the activity levels were significantly lower inT. gondii-infected mice than in the corresponding normal mice. These results suggest an association between chronic toxoplasmosis and aminopeptidase activity in the parasite-infected host brain.
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Akao, S., Yamakami, K., Nishiyama, M. et al. Aminopeptidase activity in the brains of mice with chronicToxoplasma gondii infections. Parasitol Res 75, 186–188 (1989). https://doi.org/10.1007/BF00931273
- Normal Mouse
- Antibody Production
- Brain Extract
- Aminopeptidase Activity