The successive action of alkali and hydrochloric acid on the ethyl esters of N,N-diacetyl- and 1-methyl-α-oxo-α′-(acetylmercapto) dehydrodesthiobiotin, respectively, gives 2,3,4,5-tetradehydrobiotin and its 1′-methyl derivative.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 7, pp. 1679–1681, July, 1973.
We express our gratitude to B. P. Fabrichnyi for supplying the sample of (III).
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Zav'yalov, S.I., Rubtsov, I.A., Zheleznaya, L.L. et al. Formation of 2,3,4,5-tetradehydrobiotin from α′-sulfur-containing derivatives of α-oxodehydrodesthiobiotin ethyl ester. Russ Chem Bull 22, 1641–1643 (1973). https://doi.org/10.1007/BF00930090
- Hydrochloric Acid
- Ethyl Ester