Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Alterations of functional subsets of T helper and T suppressor cell populations in acquired immunodeficiency syndrome (AIDS) and chronic unexplained lymphadenopathy

  • 20 Accesses

  • 22 Citations

Abstract

We have studied the distribution of Leu8 and Ia on T cells of the helper (T4) and suppressor (T8) phenotype in homosexual men with chronic unexplained lymphadenopathy, homosexual men with the acquired immunodeficiency syndrome (AIDS), and homosexual and heterosexual controls. Decreased numbers of helper T cells in lymphadenopathy patients are due to a decrease in the T4:Leu8+ subset, whereas in AIDS patients, both the T4:Leu8+ and the T4:Leu8 subsets were decreased.

This is a preview of subscription content, log in to check access.

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

References

  1. 1.

    Gottlieb MS, Schroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA, Saxon A: Pneumocystis carinii pneumonia and mucosal candadiasis in previously healthy homosexual men. N Engl J Med 305:1425–1431, 1981

  2. 2.

    Schroff RW, Gottlieb MS, Prince HE, Chai LL, Fahey JL: Immunological studies of homosexual men with immunodeficiency and Kaposi's sarcoma. Clin Immunol Immunopathol 27:300–314, 1983

  3. 3.

    Nicholson JKA, McDougal JS, Spira TJ, Cross GD, Jones BM, Reinherz EL: Immunoregulatory subsets of the T helper and T suppressor cell populations in homosexual men with chronic unexplained lymphadenopathy. J Clin Invest 73:191–201, 1984

  4. 4.

    Mohagheghpour N, Benike CJ, Kansas G, Bieber C, Engleman EG: Activation of antigen-specific suppressor T cells in the presence of cyclosporin requires interactions between T cells of inducer and suppressor lineage. J Clin Invest 72:2092–2100, 1983

  5. 5.

    Gatenby PA, Kansas GS, Xian CY, Evans RL, Engleman EG: Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man. J Immunol 129:1997–2000, 1982

  6. 6.

    Reinherz EL, Morimoto C, Fitzgerald KA, Hussey RE, Daley JF, Schlossman SF: Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations. J Immunol 128:463–468, 1982

  7. 7.

    Boyum A: Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21(Suppl 97):77–89, 1968

  8. 8.

    Kornfeld H, Vandestowe RA, Large M, Reddy MM, Grieco MH: T-lymphocyte subpopulations in homosexual men. N Engl J Med 307:729–731, 1982

  9. 9.

    Pinching AJ, Jeffries DJ, Donaghy M, Munday PE, McManus TJ, Moshtael O, Parkin JM, Harris JRW: Studies of cellular immunity in male homosexuals in London. Lancet 2:126–129, 1983

  10. 10.

    Tronolone M, Park BH: T-cell subsets imbalance in “healthy” homosexual males: a prospective study. IRCS Med Sci 12:7–8, 1984

  11. 11.

    Reinherz EL, Kung PC, Pesando JM, Ritz J, Goldstein G, Schlossman SF: Ia determinants on human T cell subsets defined by monoclonal antibody: Activation stimuli required for expression. J Exp Med 150:1472–1482, 1979

  12. 12.

    Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vezinel-Brun F, Rouzioux C, Rozenbaum W, Montagnier L: Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868–871, 1983

  13. 13.

    Gallo RC, Sulahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, Palker TJ, Redfield R, Oleske J, Safai B, White G, Foster P, Markham PD: Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224:500–503, 1984

  14. 14.

    Brun-Vezinet F, Barre-Sinoussi F, Saimot AG, Christol D, Montagnier L, Rouzioux C, Klatzmann D, Rozenbaum W, Gluckmann JC, Chermann JC: Detection of IgG antibodies to lymphadenopathy-associated virus in patients with AIDS or lymphadenopathy syndrome. Lancet 1:1253–1256, 1984

  15. 15.

    Safai B, Groopman JE, Popovic M, Schupbach J, Sarngadharan MG, Arnett K, Sliski A, Gallo RC: Seroepidemiological studies of human T-lymphotropic retrovirus type III in acquired immunodeficiency syndrome. Lancet 1:1438–1440, 1984

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nicholson, J.K.A., McDougal, J.S. & Spira, T.J. Alterations of functional subsets of T helper and T suppressor cell populations in acquired immunodeficiency syndrome (AIDS) and chronic unexplained lymphadenopathy. J Clin Immunol 5, 269–274 (1985). https://doi.org/10.1007/BF00929462

Download citation

Key words

  • Acquired immunodeficiency syndrome
  • immunoregulatory T cells
  • lymphadenopathy
  • homosexual men
  • T-cell subsets