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Neoplastic association of enhanced type V collagen production in rat fibrosarcoma

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Collagens present in the connective tissues of the extracellular matrix of fibrosarcoma were isolated and characterized. The fibrosarcoma was induced in rats by the administration of 3-methylcholanthrene. The results obtained were compared with normal muscle. An excess amount of type V collagen was found to be produced by the fibrosarcoma tissue compared to the normal muscle. Type V collagen from fibrosarcoma was characterized on the basis of solubility behavior in sodium chloride solutions, electrophoretic mobility on SDS-polyacrylamide gels, elution pattern of phosphocellulose chromatography and amino acid composition.

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Correspondence to G. Kesava Reddy.

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Asokan, R., Reddy, G.K. & Dhar, S.C. Neoplastic association of enhanced type V collagen production in rat fibrosarcoma. Mol Cell Biochem 120, 25–32 (1993). https://doi.org/10.1007/BF00925981

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Key words

  • extracellular matrix
  • collagen
  • fibrosarcoma