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Synthesis and properties of pyrimidinylalkylphosphonic acids

Communication 8. Reaction of hydroxypyrimidines with formaldehyde and some trivalent phosphorus derivatives

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  1. l.

    Uracils react with formaldehyde and trivalent phosphorus derivatives to give derivatives in the 5 position of the pyrimidine ring.

  2. 2.

    Amino-4-hydroxy-5-methylpyrimidine reacts with paraform and triethyl phosphite at the amino group.

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Literature cited

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    D. Purdella and R. Vylchanu, Chemistry of Organic Phosphorus Compounds [Russian translation], Khimiya (1972), p. 395.

  2. 2.

    B. E. Ivanov and S. S. Krokhina, Izv. Akad. Nauk SSSR, Ser. Khim.,1971, 2773.

  3. 3.

    G. Kenner and L. Todd, Heterocyclic Compounds. Pyrimidine and its Derivatives [Russian translation], Vol. 6, IL (1960), p. 210.

  4. 4.

    D. J. Brown, The Pyrimidines, Interscience Publishers, New York-London (1962), p. 133.

  5. 5.

    F. Perin, A. Cier, and C. Hofre, Bull. Soc. Chim. France,1964, 1877.

  6. 6.

    N. K. Kochetkov, É. I. Budovskii, E. D. Sverdlov, N. A. Simukova, M. F. Turchinskii, and V. N. Shibaev, Organic Chemistry of Nucleic Acids [in Russian], Khimiya (1970), p. 387.

  7. 7.

    K. Nakanishi, Infrared Spectra and Structure of Organic Compounds [Russian translation], Mir (1965), p. 67.

  8. 8.

    D. J. Brown, The Pyrimidines, Suppl. 1, Wiley-Interscience, New York-London (1970), p. 372.

  9. 9.

    V. S. Reznik and Yu. S. Shvetsov, Izv. Akad. Nauk SSSR, Ser. Khim., 1971, 2231.

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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 2, pp. 385–390, February, 1975.

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Reznik, V.S., Shvetsov, Y.S. Synthesis and properties of pyrimidinylalkylphosphonic acids. Russ Chem Bull 24, 314–318 (1975). https://doi.org/10.1007/BF00925776

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  • Formaldehyde
  • Phosphorus
  • Pyrimidine
  • Uracil
  • Phosphite