A number of O-ethyl O-β-alkylmercaptoethyl benzylphosphonates and their methylated iodides have been synthesized.
The O-ethyl O-β-alkylmercaptoethyl benzylphosphonates and their methylated iodides were found to be reversible inhibitors of acetylcholinesterase and butyrylcholinesterase of a competitive type.
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R. S. Agabekyan, M. Kh. Bekanov, M. Kh. Berkhamov, N. N. Godovikov, and M. I. Kabachnik, Izv. Akad. Nauk SSSR, Ser. Khim., 874 (1974).
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2095–2098, September, 1977.
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Berkhamov, M.K., Kuzamyshev, V.M., Godovikov, N.N. et al. Synthesis of O-ethyl O-β-alkylmercaptoethyl benzylphosphonates and their methylated iodides and their interactions with choline esterases. Russ Chem Bull 26, 1939–1942 (1977). https://doi.org/10.1007/BF00924394
- Choline Esterase