Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Synthesis of O-ethyl O-β-alkylmercaptoethyl benzylphosphonates and their methylated iodides and their interactions with choline esterases

  • 19 Accesses

Conclusions

  1. 1.

    A number of O-ethyl O-β-alkylmercaptoethyl benzylphosphonates and their methylated iodides have been synthesized.

  2. 2.

    The O-ethyl O-β-alkylmercaptoethyl benzylphosphonates and their methylated iodides were found to be reversible inhibitors of acetylcholinesterase and butyrylcholinesterase of a competitive type.

This is a preview of subscription content, log in to check access.

Literature cited

  1. 1.

    R. S. Agabekyan, M. Kh. Bekanov, M. Kh. Berkhamov, N. N. Godovikov, and M. I. Kabachnik, Izv. Akad. Nauk SSSR, Ser. Khim., 874 (1974).

  2. 2.

    N. N. Godovikov, R. S. Agabekyan, V. M. Kuzamyshev, M. Kh. Berkhamov, L. M. Zakharova, Z. K. Pegova, and M. I. Kabachnik, Izv. Akad. Nauk SSSR, Ser. Khim., 1606 (1977).

  3. 3.

    R. Rabinowitz, J. Am. Chem. Soc.,82, 4564 (1960).

  4. 4.

    J. L. Webb, Enzyme and Metabolic Inhibitors, Academic Press, New York (1966).

  5. 5.

    V. A. Yakovlev and R. S. Agabekyan, Biokhimiya,31, 258 (1966); R. S. Agabekyan, M. Kh. Berkhamov, N. N. Godovikov, M. I. Kabachnik, and G. G. Ol'khovaya, Izv. Akad. Nauk SSSR, Ser. Khim., 407 (1974).

Download references

Author information

Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2095–2098, September, 1977.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Berkhamov, M.K., Kuzamyshev, V.M., Godovikov, N.N. et al. Synthesis of O-ethyl O-β-alkylmercaptoethyl benzylphosphonates and their methylated iodides and their interactions with choline esterases. Russ Chem Bull 26, 1939–1942 (1977). https://doi.org/10.1007/BF00924394

Download citation

Keywords

  • Methylated
  • Iodide
  • Choline
  • Choline Esterase
  • Acetylcholinesterase