Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Synthesis of alkyl esters of N,N-bis(2-chloroethyl)carbamoyl-α-amino acids


A convenient method was proposed for the preparation of the alkyl esters of N,N-bis(2-chloroethyl)carbamoyl-α-amino acids.

This is a preview of subscription content, log in to check access.

Literature cited

  1. 1.

    L. P. Rasteikene, M. I. Degene, and I. L. Knunyants, Usp. Khim.,49, 1537 (1970).

  2. 2.

    W. A. Skinner, H. F. Gram, M. O. Greene, J. Greenberg, and B. B. Baker, J. Med. Pharm. Chem.,2, 292 (1960).

  3. 3.

    T. P. Johnston, G. S. McCaleb, P. S. Opliger, and G. A. Montgomery, J. Med. Chem.,9, 892 (1966).

  4. 4.

    O. M. Friedman and A. M. Seligman, J. Am. Chem. Soc.,70, 3082 (1948).

  5. 5.

    F. D. Popp and H. Swarz, J. Org. Chem.,26, 4764 (1961).

  6. 6.

    F. D. Popp and D. W. Alwani, Can. J. Chem.,42, 1506 (1964).

  7. 7.

    A. Ya. Berlin and I. S. Levin, Zh. Obshch. Khim.,33, 860 (1963).

  8. 8.

    G. Knedouri, J. Kim, and O. M. Friedman, J. Med. Chem.,7, 653 (1964).

  9. 9.

    S. Goldschmidt and M. Wick, Ann. Chem.,575, 217 (1952).

  10. 10.

    F. Mann, J. Chem. Soc., 461 (1934).

  11. 11.

    Yu. A. Davidovich, O. M. Galkin, and S. V. Rogozhin, USSR Patent 555091 (1977); Byull. Izobr., No. 15, 67 (1977).

  12. 12.

    A. F. Childs, L. J. Goldsworthy, G. F. Harding, F. S. King, A. W. Nineham, W. L. Norris, S. G. P. Plant, B. Selton, and A. L. L. Tompsett, J. Chem. Soc., 2174 (1948).

  13. 13.

    R. W. Chambers and F. H. Carpenter, J. Am. Chem. Soc.,77, 1522 (1955).

Download references

Author information

Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 683–685, March, 1978.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Davidovich, Y.A., Galkin, O.M. & Rogozhin, S.V. Synthesis of alkyl esters of N,N-bis(2-chloroethyl)carbamoyl-α-amino acids. Russ Chem Bull 27, 590–592 (1978).

Download citation


  • Ester
  • Convenient Method
  • Alkyl Ester