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Synthesis of pteroic acid


Pteroic acid was synthesized by starting with 2-amino-4-hydroxy-5-nitro-6-chloropyrimidine, epichlorohydrin, and p-aminobenzoic acid.

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Literature cited

  1. 1.

    N. A. Preobrazhenskii, and É. I. Genkin, Chemistry of Organic Drugs [in Russian], Goskhimizdat, Moscow (1953), p. 413.

  2. 2.

    J. Davoll and D. D. Evans, J. Chem. Soc.,1960, 5041.

  3. 3.

    C. W. Waller, B. L. Hutchings, J. H. Mowat, E. L. R. Stokstad, J. H. Boothe, R. B. Angier, J. Semb, Y. Subbarow, D. B. Cosulich, M. J. Fahrenbach, M. E. Hultquist, E. Kun, E. H. Northey, D. R. Seeger, J. P. Sickels, and J. M. Smith, Jr., J. Am. Chem. Soc.,20, 19 (1948).

  4. 4.

    W. Pfleiderer, H. Zondler, and R. Mengel, Ann. Chem.,741, 64 (1970).

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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2821–2823, December, 1976.

We express our gratitude to L. Plante for supplying the sample of (I).

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Zav'yalov, S.I., Ovechkina, L.F. & Gunar, V.I. Synthesis of pteroic acid. Russ Chem Bull 25, 2631–2633 (1976).

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  • Epichlorohydrin
  • Pteroic Acid