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Synthesis of pteroic acid

Conclusions

Pteroic acid was synthesized by starting with 2-amino-4-hydroxy-5-nitro-6-chloropyrimidine, epichlorohydrin, and p-aminobenzoic acid.

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Literature cited

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    N. A. Preobrazhenskii, and É. I. Genkin, Chemistry of Organic Drugs [in Russian], Goskhimizdat, Moscow (1953), p. 413.

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    C. W. Waller, B. L. Hutchings, J. H. Mowat, E. L. R. Stokstad, J. H. Boothe, R. B. Angier, J. Semb, Y. Subbarow, D. B. Cosulich, M. J. Fahrenbach, M. E. Hultquist, E. Kun, E. H. Northey, D. R. Seeger, J. P. Sickels, and J. M. Smith, Jr., J. Am. Chem. Soc.,20, 19 (1948).

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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2821–2823, December, 1976.

We express our gratitude to L. Plante for supplying the sample of (I).

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Zav'yalov, S.I., Ovechkina, L.F. & Gunar, V.I. Synthesis of pteroic acid. Russ Chem Bull 25, 2631–2633 (1976). https://doi.org/10.1007/BF00920917

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Keywords

  • Epichlorohydrin
  • Pteroic Acid