Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

New syntheses of pterin based on ethylenediamine and ethanolamine

Conclusions

  1. 1.

    Pterin was obtained by heating 2,6-diamino-4-hydroxy-5-nitrosopyrimidine with ethanolamine in ethylene glycol, and it is also formed by reacting 2,6-diamino-4-hydroxypyrimidine with ethylenediamine in ethylene glycol in the presence of cupric acetate and subsequent oxidation with alkaline hydrogen peroxide.

  2. 2.

    When 2,6-diamino-4-hydroxypyrimidine is reacted with benzylamine or ethanolamine in ethylene glycol in the presence of cupric acetate it, respectively, gives 6-benzylamino- or 6-(β-hydroxyethylamino)-2-amino-4-hydroxypyrimidine.

This is a preview of subscription content, log in to check access.

Literature cited

  1. 1.

    S. I. Zav'yalov, T. K. Budkova, and N. I. Aronova, Izv. Akad. Nauk SSSR, Ser. Khim.,1973, 2136.

  2. 2.

    G. B. Elion and G. H. Hitchings, J. Am. Chem. Soc.,74, 3847 (1952).

  3. 3.

    C. W. Noell and R. K. Robins, J. Med. Pharm. Chem.,5, 559 (1962).

  4. 4.

    G. B. Elion and G. H. Hitchings, J. Am. Chem. Soc.,75, 4311 (1953).

Download references

Author information

Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2819–2821, December, 1976.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zav'yalov, S.I., Ovechkina, L.F. New syntheses of pterin based on ethylenediamine and ethanolamine. Russ Chem Bull 25, 2628–2630 (1976). https://doi.org/10.1007/BF00920916

Download citation

Keywords

  • Oxidation
  • Hydrogen
  • Acetate
  • Ethylene
  • Hydrogen Peroxide