Pterin was obtained by heating 2,6-diamino-4-hydroxy-5-nitrosopyrimidine with ethanolamine in ethylene glycol, and it is also formed by reacting 2,6-diamino-4-hydroxypyrimidine with ethylenediamine in ethylene glycol in the presence of cupric acetate and subsequent oxidation with alkaline hydrogen peroxide.
When 2,6-diamino-4-hydroxypyrimidine is reacted with benzylamine or ethanolamine in ethylene glycol in the presence of cupric acetate it, respectively, gives 6-benzylamino- or 6-(β-hydroxyethylamino)-2-amino-4-hydroxypyrimidine.
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S. I. Zav'yalov, T. K. Budkova, and N. I. Aronova, Izv. Akad. Nauk SSSR, Ser. Khim.,1973, 2136.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2819–2821, December, 1976.
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Zav'yalov, S.I., Ovechkina, L.F. New syntheses of pterin based on ethylenediamine and ethanolamine. Russ Chem Bull 25, 2628–2630 (1976). https://doi.org/10.1007/BF00920916
- Hydrogen Peroxide