Fifteen patients aged 11–25 years (mean 15.37, SD 3.89) suffering from juvenile absence epilepsy are presented. Only 3 (20%) had absences (AS) as the only seizure type, 12 (80%) had associated generalized tonic-clinic seizures (GTCS) and in the remaining 3 with absences and GTCS there was also sporadic myoclonus. We found a higher frequency of AS in our patients by clinical history and video-EEG than has been previously reported. In our patients the mean age of onset in years was 11.4, SD 1.24 for AS, 13.12, SD 2.31 for GTCS and 12.5, SD 2.18 for myoclonus. The correct diagnosis was not made on referrals for any of the patients. It took an average of 3–5.5 years from the onset of the AS (range: 6–120 months) and 2 years from the occurrence of GTCS (average: 1–72 months) to make the correct diagnosis and institute proper treatment, which was valproic acid (VPA). The GTCS were controlled in all patients whereas AS continued in 6 (40%), but to a significantly lesser degree. The frequency and the duration of the GTCS before the start of VPA treatment seemed to have an adverse effect on AS control. We documented no circadian rhythm in either AS or the GTCS, except in 2 patients who had AS and GTCS mainly when they awoke in the morning. The sample size was too small to perform a proper genetic study, though a positive history of epilepsies of mixed types was obtained in 35.7% of the parents and the siblings of the probands.
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Bauer G (1973) Katamnestsiche Studien bei 3/sec-spike-and-wave Trägern. Fortschr Neurol Psychiatr 41:177–224
Beck-Manngetta G, et al (1989) Genetics of the epilepsies. Springer, Berlin Heidelberg New York, pp 34–41
Charlton MH, Yahr MD (1967) Long term follow up of patients with petit mal. Arch Neurol 16:595–598
Commission on Classification and Terminology of the Internatinal League Against Epilepsy (1989) Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 30:389–399
Dalby MA (1969) Epilepsy and 3 per second spike and wave rhythms. Acta Neurol Scand 45 [Suppl 40]
Delgado-Escueta AV, Enrile-Bascal Fe (1984) Juvenile myoclonic epilepsy of Janz. Neurology 34:285–294
Doose H, Bair WK (1987) Genetic factors in epilepsies with primarily generalized minor seizures. Neuropaediatrics 18 [Suppl 1]:1–64
Doose H, Völzke E, Scheffner D (1965) Verlaufsformen kindlicher Epilepsien mit Spike-Wave-absencen. Arch Psychiatr Nervenkr 207:394–415
Doose H, Gerken H, Horst T, Volzke E (1973) Genetic factors in spike wave absences. Epilepsia 14:57–75
Gestaut H, Zifkin BG, Mariani E, Puig JS (1986) The long-term course of primary generalized epilepsy with persisting absences. Neurology 36:1021–1028
Gibberd FB (1966) The prognosis of petit mal. Brain 89:531–538
Gowers WR (1881) Epilepsy and other chronic convulsive diseases. Churchill, London
Janz D, Christian W (1957) Impulisvepetit-male. J Neurol 176:346–386
Janz D (1969) Die Epilesien. Stuttgart, Thieme
Janz D (1985) Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy). Acta Neurol Scand 72:339–359
Metrakos JD, Metrakos K (1966) Childhood epilepsy of subcortical (centrencephalic) origin. Clin Pediatr 5:356–542
Metrakos JD, Metrakos K, Polizos P, Valle F (1966) Genetics and ontogenesis of centrecephalic EEG. Electroencephalogr Clin Neurophysiol 21:404
Obeid T, Panayiotopoulos CP (1988) Juvenile myoclonic epilepsy: a study in Saudi Arabia. Epilepsia 29:280–282
Panayiotopoulos CP, Obeid T, Waheed G (1989) Differentiation of typical absences seizures in epileptic syndromes. Brain 112:1039–1056
Reynolds EH (1987) Early treatment and prognosis of epilepsy. Epilepsia 28:97–106
Wolf P (1985) Juvenile absence epilepsy. In: Roger J, Dravet C, Bureau M, Dreifuss FE, Wolf P (eds) (1985) Epileptic syndromes in infancy, childhood and adolescence. Libbey, London, pp 242–246
Wolf P, Inoue Y (1984) Therapeutic response of absence seizures in patients of an epilepsy clinic for adolescents and adults. J Neurol 231:225–229
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Obeid, T. Clinical and genetic aspects of juvenile absence epilepsy. J Neurol 241, 487–491 (1994). https://doi.org/10.1007/BF00919710
- Juvenile absence epilepsy