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Coagulation inhibitors and glycaemic control in non-insulin-dependent diabetes mellitus

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Abstract

The relationship between long-term glycaemic control and the activity of coagulation inhibitors was investigated in 60 non-insulin-dependent diabetes mellitus (NIDDM) patients not on insulin therapy. Overall, the activities of antithrombin III (AT III) (median 96%, range 65–133%), protein C (127%, 24–190%) and protein S (130%, 54–163%) were not reduced. Patients in poor long-term glycaemic control as verified by increased glycated haemoglobin (HbA1c) demonstrated significantly decreased median AT III activity in comparison with patients in good glycaemic control (92% vs 101%,P=0.016). However, individual values for AT III activity were not below the critical limit of 60%. An inverse correlation between AT III activity and long-term glycaemic control (HbA1c) was calculated (r=−0.378,P=0.0029). As AT III concentrations were found to be normal, we propose that non-enzymatic glycation leads to reduced activity of AT III without affecting its concentration.

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Reinhardt, K.M., Burstein, C., Nagel, H. et al. Coagulation inhibitors and glycaemic control in non-insulin-dependent diabetes mellitus. Glycosylation & Disease 1, 287–291 (1994). https://doi.org/10.1007/BF00919337

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Key words

  • antithrombin III
  • glycaemic control
  • non-insulin-dependent diabetes mellitus
  • protein C
  • protein S